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Completed

NCT Number: NCT00748735

Left Ventricular Lead Position in Cardiac Resynchronization Therapy

Left ventricular (LV) lead position has crucial impact on cardiac resynchronization therapy (CRT) success. This study will compare fluoroscopy and myocardial deformation imaging for optimal definition of LV lead position.

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Key information

Conditions

Heart Failure Cardiovascular Diseases Heart Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Cardiology, RWTH Aachen University Hospital

Aachen, 52057, Germany

About this study

In a 16 segment model circumferential strain will be used to determine the segment with latest peak systolic circumferential strain prior to CRT, considered as the optimal LV lead target. LV lead will be defined by (1) fluoroscopy, (2) the maximal temporal difference of peak circumferential strain before-to-on CRT and (3) the earliest peak systolic circumferential strain during LV pacing. For all 3 modalities optimal LV lead position is defined as concordance or immediate neighbouring of the segment with defined LV lead position to the determined optimal target segment. At follow-up echocardiography will be performed to determine improvement in LV function and remodeling.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • See above
  • Males and females
  • Ages 18 to 80 years

Exclusion criteria

  • Patients who already have had a pacemaker device
  • Patients with poor echocardiographic window
  • Patients who are not able to understand the study and to give informed written consent

Treatment and study plan

Implantation of a cardiac resynchronization therapy device

Procedure

Echocardiography (myocardial deformation imaging)

Procedure

Primary outcomes

  1. Improvement in LV function and LV remodelling

    Time frame: 6 to 12 months

Sponsors and collaborators

Lead sponsor

RWTH Aachen University

Other

Registry information

Official study title

Optimal Definition of Left Ventricular Lead Position in Cardiac Resynchronization Therapy by Myocardial Deformation Imaging

Important dates

First posted
Sep 9, 2008
Registry last updated
Sep 9, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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