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Completed

NCT Number: NCT03522194

Left Ventricular Diastolic Function During Anesthesia Induction

Diastolic dysfunction is an important cause of hemodynamic instability in the perioperative field.Therefore this study aims to investigate the influence of existing diastolic dysfunction or deterioration of diastolic function on hemodynamic stability during induction of anesthesia and postoperative complications. The impact of different anesthetics on diastolic function is investigated.

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Key information

Conditions

Left Ventricular Diastolic Dysfunction Cardiovascular Diseases Heart Diseases Ventricular Dysfunction Ventricular Dysfunction, Left

Age range

60 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Universitätsklinikum Hamburg-Eppendorf

Hamburg, 20246, Germany

About this study

In this prospective observational study two cohorts of patients with different anesthesia regimes are investigated. Anesthesia is maintained with sevoflurane or propofol. Before induction of anesthesia a transthoracic echocardiography is performed to examine systolic and diastolic function. Immediately after induction, during maintenance and after completion of anesthesia any changes of diastolic function are examined with transthoracic echocardiography. All anesthetic medications, fluids, vasoactive medications and catecholamines are registered.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients older than 60 years scheduled for general anesthesia

Exclusion criteria

  • Mitral regurgitation or stenosis > I°
  • Sp. mitral valve repair or replacement
  • Pericardial effusion
  • Atrial fibrillation/flutter
  • Patients with pacemaker
  • BMI > 35 kg/m2

Treatment and study plan

Sevoflurane

Drug

Anesthesia maintenance with Sevoflurane

Propofol

Drug

Anesthesia maintenance with Propofol

Primary outcomes

  1. Norepinephrine

    Time frame: 30 minutes after induction of anesthesia

    Cumulative dose of norepinephrine (adjusted for body weight) during the first 30 minutes after induction of anesthesia

Secondary outcomes

  1. e'

    Time frame: Directly after induction of anesthesia

    Change of the echocardiographic tissue doppler parameter e' after induction of anesthesia

  2. E / e'

    Time frame: Directly after induction of anesthesia

    Change of the echocardiographic index of transmitral flow and tissue doppler after induction of anesthesia

Sponsors and collaborators

Lead sponsor

Universitätsklinikum Hamburg-Eppendorf

Other

Registry information

Official study title

Influence of Left Ventricular Diastolic Function on Hemodynamic Stability During Anesthesia Induction and on Postoperative Complications

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
May 11, 2018
Registry last updated
Mar 12, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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