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Active, Not Recruiting

NCT Number: NCT02918994

LearningRx Cognitive Training for Brain Injury

The purpose of this investigation is to conduct a series of case studies on the impact of LearningRx cognitive training on cognitive skills, daily functioning, and workplace self-efficacy for participants with Traumatic Brain Injury (TBI) /Acquired Brain Injury (ABI).

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Traumatic Brain Injury (TBI) Acquired Brain Injury Brain Diseases Brain Injuries Brain Injuries, Traumatic Central Nervous System Diseases Craniocerebral Trauma Nervous System Diseases Post COVID-19 Cognitive Impairment Trauma, Nervous System Wounds and Injuries

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Gibson Institute of Cognitive Research

Colorado Springs, Colorado, 80919, United States

About this study

The proposed study will examine the outcomes from LearningRx one-on-one cognitive training across domains on standardized measures and qualitative measures used to monitor treatment effectiveness for brain injury.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18+ previously diagnosed with TBI/ABI

Exclusion criteria

  • No braces, metal implants, or claustrophobia that would contraindicate magnetic resonance imaging for participants receiving MRI only

Treatment and study plan

LearningRx cognitive training

Behavioral

A clinician will deliver three 90-minute cognitive training sessions per week for 14 weeks. There are 16 different categories of leveled training procedures sequenced in intensity and difficulty for a total of 530 training tasks. Participants will receive training in-person or remotely depending on state of residence.

Primary outcomes

  1. Evidence of Change in Workplace Self-Efficacy

    Time frame: Baseline and 9 months

    Confirmed by change on 29-item Workplace Self-Efficacy Survey

Secondary outcomes

  1. Evidence of overall cognitive function improvement

    Time frame: Baseline and 9 months

    Confirmed by change in pretest to post-test scores on the Woodcock Johnson IV - Tests of Cognitive Abilities

  2. Evidence of Change in Self-Reported Functioning at Home and Work

    Time frame: Baseline and 9 months

    Confirmed by qualitative interview of pre-intervention symptoms and functioning and post-intervention symptoms and functioning

  3. Evidence of reduction in TBI symptoms

    Time frame: Baseline and 9 months

    As confirmed by pretest to post-test changes on the Traumatic Brain Injury Checklist (Note: for TBI participants only)

  4. Evidence of change in brain activity

    Time frame: Baseline and 9 months

    As confirmed by pretest to post-test changes in electrical activity measured by qEEG. (Note: for TBI in-person participants only; not for remote participants)

  5. Evidence of change in brain structure

    Time frame: Baseline and 9 months

    Confirmed by change in pretest to post-test neuroimaging using MRI. (Note: for in-person TBI participants only; not for remote participants.)

Sponsors and collaborators

Lead sponsor

Gibson Institute of Cognitive Research

Industry

Collaborators

  • Louisiana State University Health Sciences Center Shreveport

Registry information

Official study title

LearningRx Cognitive Training for Traumatic Brain Injury (TBI) and Acquired Brain Injury (ABI)

Important dates

Study start
2016
Primary completion
2025
Study completion
2027
First posted
Sep 29, 2016
Registry last updated
Feb 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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