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Completed

NCT Number: NCT04280367

Learning and Executive Function Disorders in Children and Psychosis Risk at Adult-age

The primary objective of the study aims to study transition toward schizophrenia in patients with learning disorders, and to compare the risk between patients with specific learning disorders, and patients with complexed learning disorders (by two types: patients with other neuro-developmental disorders including executive function disorders, and patients with anxiety).

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Key information

Age range

15 year–30 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Centre de référence des troubles du langage et des apprentissages, Hôpital Raymond Poincaré

Garches, 92380, France

About this study

As secondary objectives, the study aims to:

  • argue the clinical predicted markers (neuropsychological) transition toward psychosis.
  • test the feasibility and the acceptability of a early diagnosis for a potential applicable guidance for different referent centers of learning in French territory.
  • have a better classification of patients with learning disorders in order to target a prospective primary prevention of risk of psychosis via the questionnaires (AQ of Baron-Cohen: Autism-spectrum quotient auto-questionnaire; Inventory of Beck Anxiety Inventory, auto-questionnaire for panic disorder and general anxiety; Liebowitz Social Anxiety Scale).
  • improve identification of the early signs and the early emerging psychological diseases intervention management (schizophrenia).
  • Psychic disability: prevent and reduce non-seeking care and accompaniment situations, and risk of rupture of care.
  • permitting better care of psychosocial rehabilitation with cognitive evaluation.

This study will be conducted in Centre de référence des troubles du langage et des apprentissages, Hôpital Raymond Poincaré, APHP, in France.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients born between 1990 and 2005, have been cared by Dr Schlumberger in 2014 in the center of language and learning disorders at Raymond Poincaré hospital;
  • With severe learning disorders: deficiency in school work, need at least one medical appointment and long-term rehabilitation in the center of language and learning disorders at Raymond Poincaré hospital;
  • Affiliated to a social protection schema;
  • Written informed consent signed.

Exclusion criteria

  • Absence of learning disorder;
  • Intellectual deficiency;
  • Epilepsia;
  • Patients who will performed follow-up at Chartres city;
  • Patients under guardianship or curatorship;
  • Foreign patients under AME schema, a medical help from the state in France.

Treatment and study plan

Standardised semi-structured talk

Diagnostic Test

Comprehensive assessment of at-risk mental states (CAARMS) will be used.

Autistic spectre disorder screening

Diagnostic Test

Autism-spectrum quotient (AQ) auto-questionnaire will be used.

Anxiety measuring

Diagnostic Test

An inventory for measuring clinical anxiety: Beck Anxiety Inventory (BAI); Liebowitz Social Anxiety Scale.

Primary outcomes

  1. Semi-structured interview

    Time frame: At baseline

    Assessement with Comprehensive Assessment of At-Risk Mental States (CAARMS) during 6 to 90 minutes at the center of Raymond Poincaré hospital.

    The unique collection during the interview, quotation of each patient will be given from the assessement.

    There will be 4 groups by the results: CAARMS negative subjects, vulnerable subjects, attenuated psychosis subjects and subjects with brief and limited intermittent psychotic syndrome. The further statistic comparison will be done between the 3 last groups classified with results of CAARMS.

Secondary outcomes

  1. Autistic screening

    Time frame: At baseline

    Autism-spectrum quotient (AQ) auto-questionnaire will be used to evaluate difficulty in social interaction.

  2. Anxiety measuring

    Time frame: At baseline

    An inventory for measuring clinical anxiety: Beck Anxiety Inventory

  3. Social interaction difficulty evaluation

    Time frame: At baseline

    Liebowitz Social Anxiety Scale as questionnaire

Sponsors and collaborators

Lead sponsor

Assistance Publique - Hôpitaux de Paris

Other

Registry information

Official study title

Childhood Learning and Executive Function Disorders and Risk of Psychosis in the Adulthood

Acronym: DYS FUTURS UHR

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Feb 21, 2020
Registry last updated
Aug 22, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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