Skip to main content
OpenTrials
Enrolling by Invitation

NCT Number: NCT07221396

LDART for Stimulant Use Disorder

The goal of this study is to evaluate the feasibility, acceptability, and preliminary efficacy of a digital intervention called LDART in adults with stimulant use disorder.

Enrolling by Invitation

Interested in participating?

Request Info

Key information

Conditions

Stimulant Use Disorder Cocaine Use Disorder Methamphetamine Use Disorder

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Yale University

New Haven, Connecticut, 06520, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18 years of age or older
  • Currently reside in Connecticut, USA
  • Have a smartphone that can send and receive text messages and have internet access that can be access over the course of a month
  • Substance (Stimulant) Use Symptom Checklist ≥2, indicating past-year stimulant use disorder
  • Had high frequency of cocaine use (≥5 days) in the past 28 days
  • Have some self-reported desire to cut down or quit stimulants

Exclusion criteria

  • Unable to provide informed consent, as assessed by the consent quiz
  • Unable to speak, read, or write in English
  • Vulnerable population status
  • Unlikely to be able to complete study procedures in the next 2 months

Treatment and study plan

LDART

Device

Let's Do Addiction Recovery Together! (LDART) is a web-based intervention grounded in social cognitive theory that is designed to reduce hazardous alcohol use. It has three active ingredients: 1) daily recovery goal setting and tracking, 2) motivational video, audio, and written messages from individuals in recovery, and 3) information on several community-based recovery groups (e.g., mutual-help groups, recovery community centers) that provide free, publicly available meetings and activities. Participants receive a text message reminder each night to go to the website to complete the activities, and a text message reminder each morning of the goal they set for themselves, with the option to change it. It only takes a few minutes to use LDART each day over the 4-week intervention period.

Psychoeducational booklet

Behavioral

This is a 10-page PDF on stimulant use disorder created by the American Society of Addiction Medicine and American Academy of Addiction Psychiatry. It contains information about stimulant intoxication and withdrawal and treatment options. Participants will be encouraged to access this booklet for a few minutes each night over the 4-week intervention period.

Primary outcomes

  1. Recruitment rate

    Time frame: From enrollment to the final assessment time point (Day 56)

    The percentage of eligible participants who are enrolled relative to the total number of eligible potential participants who completed the screening.

  2. Accrual rate

    Time frame: From enrollment to the final assessment time point (Day 56)

    The rate of enrollment, defined as number of participants enrolled per month.

  3. Retention rate

    Time frame: From enrollment to the final assessment time point (Day 56)

    The percentage of enrolled participants who complete all study-related procedures (i.e., all three assessments).

  4. Intervention engagement

    Time frame: From beginning the intervention (Day 1) to the end of the intervention period (Day 28)

    Number of nights enrolled participants completed the activities on the LDART website, out of 28 nights.

  5. Intervention acceptability

    Time frame: The second assessment time point (post-intervention, Day 28)

    Rating scores on the end-user version of the Mobile App Rating Scale (uMARS). Total score range 1-5 with higher scores indicating a better quality app.

Secondary outcomes

  1. Change from baseline in stimulant use frequency

    Time frame: Baseline (Day 0), Post-intervention (Day 28), 1-month post-intervention (Day 56)

    Change in self-reported number of days when any stimulants were used in the past 28 days, as measured using the Timeline Follow-back.

  2. Change from baseline in number of hours spent engaging with recovery groups

    Time frame: Baseline (Day 0), Post-intervention (Day 28), 1-month post-intervention (Day 56)

    Self-reported number of hours spent engaging with recovery groups in the past 28 days, as measured using a modified Timeline Follow-back

Sponsors and collaborators

Lead sponsor

Yale University

Other

Collaborators

  • College on Problems of Drug Dependence

Registry information

Official study title

Pilot Study of the Digital Intervention LDART for Stimulant Use Disorder

Acronym: LDART

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Oct 27, 2025
Registry last updated
May 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.