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OpenTrials
Completed

NCT Number: NCT00705900

LCD Solution Versus Calcipotriol Cream in the Treatment of Moderate Plaque Psoriasis

The purpose of this study is to compare the safety and effectiveness of a new topical LCD solution and a commercially available calcipotriol (Vitamin D) cream in reducing the symptoms of plaque psoriasis and improving the quality of life in adults.

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Key information

Conditions

Chronic Plaque Psoriasis Psoriasis Skin Diseases Skin Diseases, Papulosquamous Skin and Connective Tissue Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Mass General Hospital: Clinical Unit for Research Trials in Skin

Boston, Massachusetts, 02114, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18 years of age or older
  • able and willing to provide written informed consent
  • diagnosed with chronic plaque psoriasis
  • 3% to 15% body surface area involved
  • in good general health

Exclusion criteria

  • other current treatments for psoriasis
  • renal or liver dysfunction
  • pregnant or nursing

Treatment and study plan

LCD

Drug

2 applications / day for 12 weeks

Calcipotriol

Drug

2 applications / day for 12 weeks

Other names: Dovonex Cream (50 mcg/g 0.005%)

Primary outcomes

  1. Difference in percent reduction in Psoriasis Area and Severity Index (PASI) Scores between treatment arms

    Time frame: 12 weeks of treatment

Secondary outcomes

  1. Changes in PLASI, PEASI, Physician Global Assessment (PGA), Pruritus, and Dermatology Life Quality Index (DLQI) Scores between treatment arms

    Time frame: Week 12 and Week 18

Sponsors and collaborators

Lead sponsor

NeoStrata Company, Inc.

Industry

Registry information

Official study title

A Randomized, Single-Blind, Active Control, 18-Week Study to Evaluate the Safety and Efficacy of A New Twice-Daily, Topically Applied LCD Solution vs. Calcipotriol Cream for the Treatment of Adult Subjects With Moderate Plaque Psoriasis

Important dates

Study start
2007
Primary completion
2008
Study completion
2008
First posted
Jun 27, 2008
Registry last updated
Nov 19, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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