Lateral Sinus Augmentation Using L-PRF as Sole Graft Material

Severe maxillary atrophy occurs after extraction of teeth in poster maxilla due to dimensional changes occur after removal; besides, sinus membrane pneumatization causes alveolar bone resorption, different classification for remaining alveolar bone in the posterior maxilla were done. In this study, the ABC sinus classification was followed in case selection. A sinus augmentation is done with several techniques. Sinus membrane elevation is done with two different approaches, either the crestal approach or lateral window approach.

Using biofiller material for sinus membrane elevation has been tried by many researchers, using a bone graft, platelet concentrates preparation, collagen membranes, tenting screws, or with implant tenting.

In this study, sinus augmentation was performed using a lateral window approach using L-PRF as sole biofiller material in one group, xenograft as only biofiller material in the second group and mixed xenograft with L-PRF in the third group. Histomorphometric analysis was done from the core biopsy after three months of augmentation, and implant placement was done.

After three months, prosthetic parts were placed. The results of this study show that the augmentation of the sinus using L-PRF mixed with bone graft is showing the best results followed by L-PRF only, and the least was xenograft.

From this point of discussion, it can be considered that using L-PRF as sole biofiller material in sinus augmentation.

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Key information

Conditions

Maxillary Diseases Jaw Diseases Musculoskeletal Diseases Stomatognathic Diseases

Age range

20 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy adult patients.
Both sex, males and females.
Age from 24 - 49 years old.
All patients were free from any systemic diseases as evidenced by Burkett's oral medicine health history questionnaire.
Extraction done at posterior maxilla involved with the maxillary sinus.
Remaining alveolar bone ≤ 5mm vertically and ≥ 4mm horizontally and from 1.5 mm to 3.5 mm vertically.
Gingival biotype 1-2mm thickness.
Patient has no previous surgery in Maxillary antrum.

Exclusion criteria

Smokers.
Pregnant and breast-feeding females.
Mentally retarded Patients.
Presence of hematologic disease.
Previous radiation, chemotherapy, or immunosuppressive treatments.
Diabetes mellitus, metabolic bone disease, ongoing treatment with bisphosphonates drugs, or pregnancy.
Patient with history of chronic sinus pathosis
Anticoagulant drugs, Endocarditis risk factors, renal and hepatic failure.

Treatment and study plan

L-PRF

Procedure

sinus augmentation using L-PRf as sole graft material

L-PRF mixed with xenograft

Procedure

sinus augmentation using L-PRF mixed with xenograft as sole graft material

xenograft

Procedure

sinus augmentation using xenograft as sole graft material

Primary outcomes

histomorphometric analysis

Time frame: 3 months

After three months from sinus augmentation, a second surgery will be done for implant placement; during this procedure, a bone core biopsy will be harvested. The biopsy will be stained with mason stain for histomorphometric analysis. The aim is to measure the newly formed bone for three months.

Sponsors and collaborators

Lead sponsor

British University In Egypt

Other

Registry information

Official study title

Lateral Sinus Augmentation Using L-PRF and Xenograft: Radiographic and Histomorphometry Analysis.

Important dates

Study start: 2016
Primary completion: 2019
Study completion: 2019
First posted: Nov 13, 2019
Registry last updated: Dec 5, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed