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NCT Number: NCT06551376

LATE LUTEAL PHASE VS. CONVENTIONAL EARLY FOLLICULAR PHASE START IN IVF

To compare cycle outcomes after scheduling with the standard early follicular phase (EFP) versus late luteal phase (LLP) in patients undergoing GnRH antagonist cycles.

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Key information

Conditions

IVF

Age range

20 year–42 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

About this study

Objective To compare cycle outcomes after scheduling with the standard early follicular phase (EFP) versus late luteal phase (LLP) in patients undergoing GnRH antagonist cycles.

Design Multicentric prospective non-randomized study

Setting Two university-affiliated private assisted reproduction centers.

Patient(s) Regularly cycling women aged ≤40 years with fewer than one previous IVF attempts were enrolled. Previous low responses to controlled ovarian hyperstimulation, ovarian surgery, or polycystic ovary were exclusion criteria.

Intervention(s) Twenty patients started controlled ovarian stimulation (COS) after spontaneous menses; similarly, twenty patients started stimulation on the Friday previous to a spontaneous menses (at the end of late luteal phase), regardless of cycle day.

Main Outcome Measure(s) Primary outcome: number of mature oocytes retrieved. Secondary outcomes: fertilization rate, viable embryo rate per oocyte retrieved, cancellation rate, and clinical pregnancy outcomes from FET cycles.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Regularly cycling women aged ≤40 years with fewer than one previous IVF attempts were enrolled

Exclusion criteria

  • Previous low responses to controlled ovarian hyperstimulation, ovarian surgery, or polycystic ovary were exclusion criteria

Treatment and study plan

Ovarian Stimulation Start

Other

To compare ovarian response accordin to ovarian stimualtion start

Primary outcomes

  1. mature oocytes retrieved

    Time frame: At retrieval

Secondary outcomes

  1. fertilization rate

    Time frame: 24 hours after retrieval

  2. viable embryo rate per oocyte retrieved

    Time frame: 5 days after retrieval

  3. cancellation rate

    Time frame: 14 days after cycle start

Study contacts

Contact information is provided by the study sponsor or research team.

Jorge Rodriguez-Purata, MD

CONTACT

[email protected]

55 4246 9686

Sponsors and collaborators

Lead sponsor

Clinia de fertilización Asistida en el Hospital ABC

Other

Registry information

Official study title

IVF CYCLE SCHEDULING WITH LATE LUTEAL PHASE VS. CONVENTIONAL EARLY FOLLICULAR PHASE START TO AVOID WEEKENDS RETRIEVALS: PROOF OF CONCEPT

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Aug 13, 2024
Registry last updated
Aug 13, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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