Laser Therapy to Treat the Dry Mouth of Sjogren's Syndrome

The Xerostomia Inventory (XI) is an 11-item questionnaire (Thomson et al, 1999). Scores to the 11 items are summated, providing a single score (5-55) representing the subjective severity of xerostomia. In 2012, da Mata published a validated version in portuguese and we used this version. The better score is the lowest. The significant variation is defined as 6 or more.

Bellow we describe all the 11 questions:

• I sip liquids to aid in swallowing food
• My mouth feels dry when eating a meal
• I get up at night to drink
• My mouth feels dry
• I have difficulty in eating dry foods
• I suck sweets or cough lollies to relieve dry mouth
• I have difficulties swallowing certain foods
• The skin of my face feels dry
• My eyes feel dry
• My lips feel dry
• The inside of my nose feels dry __________________________________________________________

Score:

Never' (1), Hardly ever' (2), Occasionally' (3), Fairly often' (4), Very often' (5)

The saliva in Sögren's syndrome patients has a high level of beta 2 microglobulin reflecting progression of the disease and inflammatory process at glandular epithelium.

The saliva samples were collected at the baseline and end point. Beta 2 microglobulin was determined by Elisa human kit (ABCAM ab 108885).

The normal levels are 1,2 +/- 0,7 microg/ml, and for primary Sjögren's syndrome 5,3 +/- 4,6 microg/ml.

This measure was done in the samples of saliva before and after the lasertherapy for all patients.

The salivary flux was measured at the same time, without previous meal or tooth brushing, drinking or eating, in a quiet room. Spilled saliva was collected in a graduated Falcon 15ml tube. The samples of saliva were frozen and stored at -20° C.

Normal salivary stimulated flux is above 0,5 ml/min. Normal unstimulated salivary flux is above 0,2 ml/min.