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OpenTrials
Completed

NCT Number: NCT04070170

Laser Therapy on Orthodontic Tooth Movement

The aims of this study will be to evaluate if a Lower Level Laser Therapy (LLLT): (1) enhances the levels of important pro-inflammatory chemokines involved in the bone remodeling process; (2) increases the rate of orthodontic tooth movement (OTM) on human subjects.

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Key information

Conditions

Laser Therapy Bone Remodeling Orthodontic Tooth Movement

Age range

13 year–18 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Pontifical Catholic University of Minas Gerais

Belo Horizonte, Minas Gerais, 30535-901, Brazil

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Facial convexity
  • Protrusion or biprotrusion of the incisors
  • Dental crowding
  • Healthy periodontal condition
  • Satisfactory oral hygiene

Exclusion criteria

  • Patients under medications that may interfere with bone metabolism, such as anti-inflammatory, antibiotics and hormonal supplements in the previous three months
  • Skeletal crossbite
  • Parafunctional habits
  • Occlusal interference

Treatment and study plan

Low-Level Laser Therapy

Device

Low-level laser therapy is applied on premolars that will be extracted for treatment plan reasons

Orthodontic force

Procedure

Mechanical loading is applied on premolars that will be extracted for treatment plan reasons and in canines for tooth movement

Primary outcomes

  1. Rate of orthodontic tooth movement, with and without low-level laser therapy

    Time frame: The quantification of OTM was performed before canine retraction

    The canine retraction was measured with a digital dynamometer

  2. Rate of orthodontic tooth movement, with and without low-level laser therapy

    Time frame: The quantification of OTM was performed after 1 month of canine retraction

    The canine retraction was measured with a digital dynamometer

  3. Rate of orthodontic tooth movement, with and without low-level laser therapy

    Time frame: The quantification of OTM was performed after 2 months of canine retraction

    The canine retraction was measured with a digital dynamometer

  4. Rate of orthodontic tooth movement, with and without low-level laser therapy

    Time frame: The quantification of OTM was performed after 3 months of canine retraction

    The canine retraction was measured with a digital dynamometer

Secondary outcomes

  1. Chemokine levels in the periodontal tissue after LLLT and orthodontic force

    Time frame: The chemokine levels were assayed on days 0, 1, 7 and 14 after application of orthodontic force and low-level laser therapy

    The chemokine levels were measured in the periodontal tissue after LLLT and orthodontic force by means of a cytometric bead array (CBA)

Sponsors and collaborators

Lead sponsor

Ildeu Andrade Jr.

Other

Registry information

Official study title

The Effects of Lower Level Laser Therapy on Orthodontic Tooth Movement

Important dates

Study start
2014
Primary completion
2018
Study completion
2019
First posted
Aug 28, 2019
Registry last updated
Sep 24, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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