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Completed

NCT Number: NCT02386163

Large-scale ex Vivo Expansion and Characterization of Two Kinds of MSC From Knee for Clinical Application

According to many researches, mesenchymal stem cells (MSC) isolated from synovial membrane and infrapatellar fat pad have higher ex vivo proliferation capacity, multipotency and ability to undergo chondrogenesis.

Based on this concept, the investigators plan to get two removed tissues (synovial membrane and infrapatellar fat pad) from patients who have an operation of TKR (Total Knee Replacement). The investigators are going to isolate and expand MSC from these two tissues respectively, and then compare their characterization and potential for clinical application. In the other hand, the investigators plan to build techniques and procedures which comply with "Good Tissue Practices (GTP)".

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Key information

Conditions

Knee Injuries Leg Injuries Wounds and Injuries

Age range

20 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Far Eastern Memorial Hospital

New Taipei City, Taiwan, 220

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patient who have an total knee replacement surgery

Exclusion criteria

Patient who don't sign the agreement

Treatment and study plan

MSC from synovial membrane and infrapatellar Fat Pad

Biological

Primary outcomes

  1. Compare MSCs from synovial membrane and infrapatellar fat pad

    Time frame: 2 months

    Comparison items include doubling time, phenotype, chondrogenesis and biological activity.

Sponsors and collaborators

Lead sponsor

EMO Biomedicine Corporation

Industry

Collaborators

  • Far Eastern Memorial Hospital

Registry information

Official study title

Large-scale ex Vivo Expansion and Characterization of Synovial Membrane MSC (SM-MSC) and Infrapatellar Fat Pad MSC (IF-MSC) for Clinical Application

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
Mar 11, 2015
Registry last updated
Sep 10, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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