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OpenTrials
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NCT Number: NCT07461090

Laparoscopic Versus Open Nephrectomy : Clinical Effectivness and Cost Analysis

To evaluate and compare clinical effectiveness (operative time, blood loss, hospital stay, complications and etc) and cost analysis' between laparoscopic nephrectomy and open nephrectomy .

Recruiting

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Key information

Age range

1 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Menoufia Faculty of Medicine

Shibīn al Kawm, Shebin Elkom, 32111, Egypt

Location status: Recruiting

Location contact

Mohamed Ibrahim Abozaid

CONTACT

[email protected]

+20 10 68588750

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • American Society of Anesthesiology score 1-3.
  • Indication for :
  • Simple total nephrectomy or hemi nephrectomy: benign chronic inflammatory non-functioning kidney
  • Partial nephrectomy: localized renal mass ≤7 cm suitable for nephron-sparing surgery.
  • Radical nephrectomy or Radical nephrouretrectomy with bladder cuff: localized renal tumor requiring complete nephrectomy without major vascular invasion.
  • Patient deemed fit for general anesthesia and surgery.
  • Patient provides written informed consent.

Exclusion criteria

  • emergency surgery, dialysis-dependent patients, planned hybrid procedures.
  • Patients with incomplete data
  • Patients with metastatic disease at presentation.
  • Prior extensive ipsilateral retroperitoneal surgery or severe adhesions precluding Laparoscopy.
  • Need for concomitant major procedures (eg, large bowel resection) at index operation.
  • Locally advanced tumor with obvious major vascular involvement requiring complex vascular reconstruction.
  • Uncorrected coagulopathy.
  • Pregnancy or Obese patient (BMI > 40)
  • Inability to provide informed consent or comply with follow-up.

Treatment and study plan

open or laparoscopic nephrectomy

Procedure

compare post operative recovery , estimated blood loss and cost analysis between open and laparosopic nephrectomy.

Primary outcomes

  1. Length of hospital stay (LOS).

    Time frame: 30 days post operative

    Number of calendar days from date of index surgery to date of discharge .

Secondary outcomes

  1. clinical effectiveness

    Time frame: Post operative 30 days.

    Functional recovery was evaluated using a modified World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0).

    The questionnaire consists of 10 items scored on a 5-point scale (0-4), with a total score ranging from 0 to 40, where higher scores indicate worse functional outcome and greater disability while Lower scores indicate better functional recovery.

Study contacts

Contact information is provided by the study sponsor or research team.

Haitham Badr Elnaggar

CONTACT

[email protected]

01003247485 ext. 002

Sponsors and collaborators

Lead sponsor

Menoufia University

Other

Registry information

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Mar 10, 2026
Registry last updated
Mar 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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