Skip to main content
OpenTrials
Completed

NCT Number: NCT00957710

Language Treatment for Progressive Aphasia

Progressive aphasia is characterized by a steady and progressive loss of language skills in the presence of relatively preserved memory, attention, and thinking. The aim of this study is to slow the progression of language decline in progressive aphasia via language therapy. The first goal of this study is to improve naming abilities of individuals with progressive aphasia. This will be accomplished by carrying out an intensive treatment program for anomia. The second goal is to evaluate whether this intense language treatment re-activates affected areas and/or connections within the language network, using functional Magnetic Resonance Imaging (to measure neural activity in specific brain regions) and Diffusion Tensor Imaging tractography (to measure the connectivity between specific brain regions). This is the first study on progressive aphasia addressing both treatment and imaging in the same patients.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Primary Progressive Aphasia Aphasia Aphasia, Primary Progressive Brain Diseases Central Nervous System Diseases Communication Disorders Dementia Frontotemporal Dementia Frontotemporal Lobar Degeneration Language Disorders Mental Disorders Metabolic Diseases Nervous System Diseases Neurobehavioral Manifestations Neurocognitive Disorders Neurodegenerative Diseases Neurologic Manifestations Nonfluent Progressive Aphasia Nutritional and Metabolic Diseases Pathological Conditions, Signs and Symptoms Primary Progressive Nonfluent Aphasia Proteostasis Deficiencies Semantic Dementia Signs and Symptoms Speech Disorders TDP-43 Proteinopathies

Age range

40 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Baycrest

Toronto, Ontario, M6A 2E1, Canada

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosis of progressive aphasia
  • Native English speaker or fluent in English
  • Adequate hearing and vision (not requiring more than +6 diopter correction)
  • Willing and able to participate in each phase of the study (including two fMRI sessions)

Exclusion criteria

  • Contraindications to fMRI (e.g., claustrophobia, pacemaker, ferromagnetic implant)
  • Current medical or psychiatric condition affecting cognition (other than progressive aphasia)

Treatment and study plan

Errorless learning

Behavioral

Language testing,20 sessions of language therapy, and 2 neuroimaging sessions for participants with progressive aphasia Language testing and 1 imaging session for healthy controls

Other names: treatment for anomia

Primary outcomes

  1. Accuracy of picture naming

    Time frame: 3 months

Secondary outcomes

  1. Changes on neuroimaging

    Time frame: 3 months

Sponsors and collaborators

Lead sponsor

Baycrest

Other

Collaborators

  • Canadian Institutes of Health Research (CIHR)

Registry information

Official study title

Slowing Language Decline in Progressive Aphasia Through Language Rehabilitation: Treatment and Neuroimaging Study

Important dates

Study start
2009
Primary completion
2010
Study completion
2010
First posted
Aug 12, 2009
Registry last updated
Jan 27, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.