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Recruiting

NCT Number: NCT05217043

Language Acquisition in the Brain and Algorithms: Towards Systematic Monitoring of the Evolution of Semantic Representations in Biological and Artificial Neural Networks

Speech depends on our ability to recursively combine successive words into a complex sense. Although the order of these putative operations (syntax) has been the subject of extensive examination in the way in which the human brain learns to perform a "Semantic composition" remains largely unknown.

The Rothschild Hospital houses a unit specializing in drug-resistant epilepsy in children from 2 to 20 years old.

The identification of the epileptogenic zone often requires making an iEEG recording for a week (implantation of intracerebral electrodes in depth).

Sometimes this recording has to be repeated, providing a unique opportunity to directly record brain activity at different periods of its development.

Children will listen to pre-recorded phrases and stories such as "The Little Prince of Antoine de Saint-Exupéry" while being recorded with iEEG.

Recruiting

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Fondation Ophtalmologique de Rothschild

Paris, France, 75019

Location status: Recruiting

Location contact

Pierre Bourdillon

CONTACT

[email protected]

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Any patient benefiting from a long-term intracranial brain recording.
  • Non-opposition to participating in the study (adult patients)
  • Non-opposition of at least one of the holders of the exercise of parental authority (minor patients)

Exclusion criteria

  • Patient with complete deafness

Treatment and study plan

intracranial brain recording

Other

Any patient benefiting from a long-term intracranial brain recording.

Primary outcomes

  1. This is a non-clinical research study investigating from intracranial recordings how speech representation changes throughout human development.

    Time frame: maximum 21 days

    intracranial recordings

Study contacts

Contact information is provided by the study sponsor or research team.

Amélie YACHITZ

CONTACT

[email protected]

(0)148036454

Sponsors and collaborators

Lead sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Network

Registry information

Acronym: SYNTAXE

Important dates

Study start
2022
Primary completion
2027
Study completion
2027
First posted
Feb 1, 2022
Registry last updated
Jan 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.