LAMICTAL (Lamotrigine) For The Treatment Of Absence Seizures

This is an open-label study evaluating the efficacy and safety of lamotrigine (LTG) for the treatment of newly-diagnosed typical absence seizures. Subjects will be children and adolescents < 13 years of age. It will be conducted at multiple sites in the US. The study will consist of 4 phases: Screen Phase (up to 1 week), Baseline Phase (24 hours), Escalation Phase (up to 20 weeks) and Maintenance Phase (12 weeks). Subjects will receive increasing doses of LTG according to the dosing schedule until attaining seizure freedom as confirmed by hyperventilation (HV) for clinical signs and a 1-hr EEG at 2 consecutive weekly visits. At that point, subjects will move into the 12-week Maintenance Phase. Subjects who do not achieve seizure freedom upon reaching the maximum dose (10.2mg/kg/day) with the specified dose escalation will be discontinued from the study. During the Maintenance Phase, the investigators will use their best effort to maintain the subjects at the efficacious dose reached. If the subjects have unacceptable side effects or inadequate seizure control, the doses of study drug can be increased or decreased as specified in the dosing schedule. Safety will be assessed by monitoring adverse events, laboratory assessments, and serum lamotrigine levels. Health outcomes assessments will also be conducted.

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Key information

Conditions

Seizure, Absence Brain Diseases Central Nervous System Diseases Epilepsy Nervous System Diseases Neurologic Manifestations Pathological Conditions, Signs and Symptoms Seizures Signs and Symptoms

Age range

Up to 12 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

GSK Investigational Site, San Jose, California, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Newly-diagnosed with absence epilepsy and never been treated with Anti-epileptic drugs (AEDs).
Diagnosis demonstrated on one of two 5-minute hyperventilation tests.
Investigator must judge that the subject and parent/guardian are likely to comply with all study procedures.
Parent/guardian must given written informed consent. Subjects who are intellectually able to understand the concepts and procedures of the protocol must give assent by also signing the consent or by signing a separate assent form.
Results of all screen assessments are judged to be clinically acceptable to the investigator and do not indicate any reasons why entry into the study would be contraindicated.

Exclusion criteria

Seizures are the result of a currently active, known, and identifiable intracerebral lesion.
Has partial or generalized tonic-clonic seizures.
Has a progressive neurological disorder defined as being unstable for at least 12 weeks prior to the Screen Phase.
Has a psychiatric disorder requiring medication, or has had a past psychiatric condition that was both judged to be severe and required hospitalization.
Has any clinically significant chronic cardiac, renal, or hepatic medical condition.
Has a condition that affects the absorption, distribution, metabolism, or excretion of drugs.
Is currently taking any psychoactive drugs to treat hyperactivity disorder or attention deficit disorder.
Has taken any investigational drug within 12 weeks prior to the Screen Phase.
Is sexually active.
Is either pregnant (i.e., confirmed by pregnancy test at Screen) or breastfeeding.
Has a clinically significant chronic medical disorder which the investigator and/or GSK medical monitor determine warrants exclusion.

Treatment and study plan

Lamotrigine

Drug

Lamotrigine will be given as chewable dispersible tablets with dosing strengths of 2, 5, 25, and 100 milligrams.

Primary outcomes

The proportion of subjects with no typical absence seizures for two consecutive weeks as confirmed by hyperventilation (HV) for clinical signs and 1-hour electroencephalogram (EEG)

Time frame: Up to 8 months

Secondary outcomes

Freq of seizures pre/post-treatment with lamotrigine, proportion of subjects with >=25, 50 and 75% decrease in seizure frequency, proportion of subjects with >=25, 50 and 75% decrease in clinical signs.

Time frame: Up to 8 months

Sponsors and collaborators

Lead sponsor

GlaxoSmithKline

Industry

Registry information

Official study title

Evaluation of Lamotrigine in Subjects With Absence Seizures

Important dates

Study start: 2004
Primary completion: 2006
Study completion: 2006
First posted: Sep 5, 2005
Registry last updated: Sep 29, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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