Lactate Levels Correlates With Ki-67 in Brain Tumor Surgery

In neurosurgery, brain tumor patients show increased levels of lactate at the beginning of surgery. This has been related to malignancy. Ki-67 is a cell proliferation index used as a marker of tumor mitotic activity.

This research aims to describe the correlation between lactate levels and the Ki-67 index in patients with brain tumor.

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Key information

Conditions

Brain Tumor Anesthesia Brain Diseases Brain Neoplasms Central Nervous System Diseases Central Nervous System Neoplasms Neoplasms Neoplasms by Site Nervous System Diseases Nervous System Neoplasms

Sex eligibility

All sexes

Study type

Observational

Primary location

Anesthesia department, Hospital Clínic de Barcelona

Barcelona, 08036, Spain

About this study

Lactate levels are used in the evaluation of perfusion status in critical care. Increases not related to a hypoperfusion state are observed in the patient with brain tumors. These increases have been related to type and tumor grade. This observation does not fully explain the variation within the same tumor grade.

Ki-67 label index is a marker of mitotic activity that can be used as proliferation index. It has been associated with histologic grade and survival rate. Provides a quantitative measure of the tumor proliferation status.

The investigators will perform a retrospective analysis of the clinical charts of patients after brain tumor resection. The study will address the relationship between baseline lactate levels and the proliferation index found in tissues biopsies.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Neurosurgical craniectomy cases
June 2017 - February 2018
Valid lactate information after anesthesia induction
Ki-67 label index informed in biopsies
Tumor type information confirmed in biopsies

Exclusion criteria

Incomplete lactate or Ki-67 index information

Treatment and study plan

Data correlation

Other

Correlation between lactate levels and Ki-67 index

Primary outcomes

Evaluate the correlation between Lactate levels and Ki-67 Index

Time frame: Within 1 week after data acquisition

Levels of lactate in first blood analysis after anesthesia induction and proliferation index in biopsy results

Sponsors and collaborators

Lead sponsor

Ricard Valero

Other

Registry information

Official study title

Lactate Levels at Beginning of Surgery Correlates With Ki-67 Labeling Index in Brain Tumors

Important dates

Study start: 2018
Primary completion: 2018
Study completion: 2018
First posted: May 21, 2018
Registry last updated: Feb 15, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed