LAAO With DAPT Versus Antithrombotic Therapy

This study will retrospectively review and compare clinical outcomes between left atrial appendage occlusion with dual antiplatelet therapy versus conventional antithrombotic therapy in patients with atrial fibrillation undergoing drug-eluting stent implantation.

Completed

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Key information

Conditions

Atrial Fibrillation Arrhythmias, Cardiac Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Artery Disease Coronary Disease Heart Diseases Myocardial Ischemia Pathologic Processes Pathological Conditions, Signs and Symptoms Vascular Diseases

Sex eligibility

All sexes

Study type

Observational

About this study

Composite of stroke and major bleeding will be compared after adjusting those groups using inverse probability weighted model.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients with AF who underwent PCI and treated with LAAO and DAPT or conventional antithrombotic therapy

Exclusion criteria

Treatment and study plan

ACP or Watchman

Procedure

Left atrial appnedage occlusion using ACP or Watchman

Primary outcomes

Composite of stroke and major bleeding

Time frame: From date of index procedure until the date of primary endpoint occur or date of last follow up, whichever came first, assessed up to 50 months

Primary endpoint is a composite of stroke and major bleeding. Stroke is defined as ischemic cerebrovascular event included both transient ischemic attack and ischemic cerebral infarction. Major bleeding event was defined as moderate or severe bleeding according to the Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries criteria.

Sponsors and collaborators

Lead sponsor

Korea University Anam Hospital

Other

Collaborators

Gachon University Gil Medical Center
Sejong General Hospital
Severance Hospital
Ulsan University Hospital

Registry information

Official study title

Comparison of Clinical Outcomes Between Left Atrial Appendage Occlusion With Dual Antiplatelet Therapy Versus Conventional Antithrombotic Therapy in Patients With Atrial Fibrillation Undergoing Drug-eluting Stent Implantation

Important dates

Study start: 2016
Primary completion: 2017
Study completion: 2017
First posted: Oct 16, 2017
Registry last updated: Oct 16, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed