LAAM-HAART PET Imaging

Inclusion

Each subject must meet all of the following criteria:

• Male or non-pregnant female volunteer, 18-50 yr old
• Good general health with no known major medical conditions
• BMI < 33
• Provide informed consent

Exclusion criteria

Subjects will not be enrolled if any of the following criteria exist:

• Known history of liver or kidney disease
• History of major medical conditions
• HIV seropositive
• Fasting blood glucose > 110 mg/dl (because HAART can cause glucose intolerance)
• Family history of type 2 diabetes
• Use of prescription or non prescription medications, herbals or foods known to be metabolized by or altering P-glycoprotein or CYP3A (hormonal birth control medications are acceptable if alternative means of contraception are used)
• Females who are pregnant or nursing
• Females taking hormonal contraceptives who are unwilling to use alternative means of contraception
• Contraindications to MRI (e.g., metal implants or splinters in the body; a worn or implanted medical device, such as a pacemaker or drug pump; inability to lie flat for up to one hour; claustrophobia) or contraindications to PET scanning (e.g., inability to lie flat for up to one hour, claustrophobia, current
• Current or recent (within 12 months prior to screening) participation in research studies involving radiation exposure such that the total research-related radiation dose to the subject in any given year would exceed the limits set forth in the US Code of Federal Regulations (CFR) Title 21 Section 361.1 (http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?FR=361.1))