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NCT Number: NCT07102758

L-PRF vs Connective Tissue With Customized Healing Abutment in Immediate Implant Placement

comparison between L-prf and connective tissue with dental implant

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Key information

Conditions

Recession, Gingival Bone Loss in Jaw Gingival Diseases Gingival Recession Mouth Diseases Periodontal Atrophy Periodontal Diseases Stomatognathic Diseases

Age range

21 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Kafrelsheikh University

Kafr ash Shaykh, Kafrelsheikh, Egypt

Location status: Recruiting

Location contact

Enas Ahmed Elgendy, Dean of Faculty of Dentistry

CONTACT

[email protected]

0201003508797

Enas Ahmed Elgendy, Dean of Faculty of Dentistry

PRINCIPAL_INVESTIGATOR

About this study

comparison between L-PRF and Connective tissue with customized healing abutment regaring soft and hard tissue outcomes with immediate dental implants.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Intact labial/buccal bone plate
  • The presence of non-restorable single-rooted maxillary centrals, canines or premolars.
  • Sufficient bone volume.
  • Good oral hygiene.
  • Nonsmokers.
  • Sufficient bone width (≥ 1 mm) in the buccal plate of the remaining bone to place an implant confirmed by cone beam computer tomography (CBCT).

Exclusion criteria

  • Insufficient bone volume.
  • Active infection.
  • Patients on chemotherapy or radiotherapy.
  • Patients who have systemic disorders {uncontrolled diabetes mellitus, autoimmune disease, …etc},
  • Pregnant patients,
  • Patients with bone diseases
  • Presence of periapical pathology.

Treatment and study plan

L-PRF with dental implant and customized healing abutment

Procedure

L-PRF with dental implant and customized healing abutment

Connective tissue with dental implant and customized healing abutment

Procedure

Connective tissue with dental implant and customized healing abutment

Primary outcomes

  1. Patient-reported pain experience

    Time frame: first 7 days after surgery

    Pain experience after surgery is daily measured by the patients using a visual analogue scale (VAS) in the first postoperative 7 days, with Day 0 being the day of the surgery. Before going to sleep, patients will be asked to mark the VAS that best represented the average pain they had experienced during the day.

  2. Pink aesthetic score

    Time frame: before surgery, 3 months and 6 months after surgery

    Parameters are : 0,1 and 2.

    Mesial papilla : 0 ( Missing ) , 1 ( Incomplete ) and 2 ( Complete ).

    Distal Papilla : 0 ( Missing ) , 1 ( Incomplete ) and 2 ( Complete ).

    Tissue contour : 0 ( Unnatural) , 1 ( virtually natural ) and 2 ( natural).

    Gingival level : 0 ( >2mm) , 1 ( 1-2mm ) and 2 ( 1 mm).

    Alveolar process : 0 ( clearly resorbed ) , 1 ( slightly resorbed ) and 2 ( no difference).

    Coloring : 0 ( clear difference ) , 1 ( slight difference ) and 2 ( no difference).

    Texture : 0 ( clear difference ) , 1 ( slight difference ) and 2 ( no difference).

  3. crestal bone loss

    Time frame: preoperative and 6 months post operative

    distance from implant shoulder to marginal bone

Secondary outcomes

  1. Gingival thickness

    Time frame: pre opearative, 3 and 6 months post operative

    1 mm apical to gingival margin in mid buccal

  2. probing pocket depth

    Time frame: preoperative , 3 and 6 months post operative

    mid buccal , mesio buccal , disto buccal and mid palatal

  3. keratinized tissue width

    Time frame: preoperative , 3 and 6 months post operative

    in mid buccal, from gingival margin to mucogingival junction

Study contacts

Contact information is provided by the study sponsor or research team.

Ahmed Atef Salem, General doctor

CONTACT

[email protected]

0201007737797

Sponsors and collaborators

Lead sponsor

Kafrelsheikh University

Other

Registry information

Official study title

Evaluation of Soft and Hard Tissue Augmentation by Connective Tissue Graft or Leukocyte-Platelet Rich Fibrin in Immediate Implant Placement With Customized Healing Abutment: A Randomized Controlled Clinical Trial.

Important dates

Study start
2025
Primary completion
2026
Study completion
2027
First posted
Aug 5, 2025
Registry last updated
Aug 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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