KTRSensor Scotland Study: An Observational Study Into Predictors and Diagnosis of Kidney Transplant Rejection

An observational study capturing real world transplant patients in the post-operative setting aiming to further determine the utility of biomarkers to improve outcomes.

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Key information

Conditions

Kidney Transplant Chronic Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Disease, Chronic Kidney Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urogenital Diseases Urologic Diseases

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Royal Infirmary of Edinburgh, Edinburgh, United Kingdom

About this study

A prospective longitudinal observational study capturing patients receiving kidney transplants in Scotland. The primary objective is to assess whether there are clinical biomarkers present in the urine that determine the outcome of kidney transplants and predict early graft rejection.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Any patient within a Scottish Transplant centre who has undergone renal transplant (+/- pancreas/islet) and is due to attend routine follow-up appointments at the index centre.

Exclusion criteria

no previous kidney transplant
patient attending follow-up at a peripheral site
unable to provide urine samples across the study duration

Treatment and study plan

Primary outcomes

Number of participants that experience acute transplant rejection

Time frame: 12 months

Defined by gold standard core biopsy, reported using the Banff histology grading.

Study contacts

Contact information is provided by the study sponsor or research team.

Alexander J Le Saint-Grant, MBChB

CONTACT

[email protected]

+44 131 651 8100

Sponsors and collaborators

Lead sponsor

University of Edinburgh

Other

Registry information

Official study title

KTRSensor Scotland Study: Investigating the Role of Biomarkers in Kidney Transplant Outcomes

Acronym: KTRSensors

Important dates

Study start: 2025
Primary completion: 2028
Study completion: 2028
First posted: Feb 17, 2025
Registry last updated: Feb 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed