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Completed

NCT Number: NCT05869513

Krill Oil and Resistance Exercise in Older Adults

The aim of this study is to determine whether krill oil supplementation enhances effects of a pragmatic resistance exercise programme on adaptations in muscle strength, mass, function and neuromuscular function in sedentary older adults. Hypothesis - krill oil supplementation will enhance the beneficial effects of resistance exercise on muscle strength, function, mass and neuromuscular function in sedentary older adults.

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Key information

Conditions

Sarcopenia Atrophy Behavior Motor Activity Muscular Atrophy Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

60 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Glasgow

Glasgow, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Over the age of 60 years
  • scoring a low level of physical activity based on international physical activity questionnaire (not meeting the recommend physical activity which is at least 600 MET-min per week).

Exclusion criteria

  • Diabetes
  • severe cardiovascular disease
  • seizure disorders
  • uncontrolled hypertension (>150/90mmHg at baseline measurement)
  • cancer or cancer that has been in remission <5 years
  • ambulatory impairments which would limit ability to perform assessments of muscle function
  • dementia
  • taking medication known to affect muscle (e.g. steroids)
  • have an implanted electronic device (e.g. pacemaker/defibrillator/insulin pump)
  • on anticoagulant therapy
  • allergies to seafood
  • regular consumption of more than 1 portion of oily fish per week
  • already taking fish or krill oil or other n3 PUFA supplements
  • femoral neck fracture or other severe of hip or knee operations
  • stroke
  • Parkinson's disease
  • COPD
  • kidney disease
  • hyperlipidaemia
  • obesity
  • osteoporosis.

Treatment and study plan

Vegetable oil

Dietary Supplement

Mixed vegetable oil

Krill oil

Dietary Supplement

Superba Krill Oil

Home-based resistance exercise

Other

Home based resistance band and body weight exercise

Primary outcomes

  1. Nueromuscular Junction (NMJ) transmission instability

    Time frame: Change from baseline to 16 weeks

    NMJ transmission instability will be measured by iEMG

Secondary outcomes

  1. Knee extensor maximal torque

    Time frame: Change from baseline to 8 16 weeks

    Knee extensor maximal torque will be measured by a load cell

  2. 30s chair stand test

    Time frame: Change from baseline to 16 weeks

    measuring the functional abilities

  3. Gait speed

    Time frame: Change from baseline to 16 weeks

    measuring the functional abilities

  4. Force steadiness during submaximal isometric knee extensor contractions

    Time frame: Change from baseline to 16 weeks

    Steadiness of force whilst contracting

  5. Red Blood Cell Omega-3 levels

    Time frame: Change from baseline to 16 weeks

  6. Grip strength

    Time frame: Change from baseline to 16 weeks

    Grip strength will be measured by handgrip dynamometer

  7. Muscle thickness

    Time frame: Change from baseline to 16 weeks

    Vastus Lateralis muscle thickness will be measured by ultrasound

Other outcomes

  1. Step Time (sec)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  2. Cycle Time (sec)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  3. Step Length (cm)

    Time frame: Change from baseline to16 weeks

    Measured during a 4m walk using a gaitrite mat

  4. Stride Length (cm)

    Time frame: Change from baseline to16 weeks

    Measured during a 4m walk using a gaitrite mat

  5. H-H Base Support (cm)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  6. Single Support (%GC)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  7. Double Support (%GC)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  8. Swing (%GC)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  9. Stance (%GC)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  10. Step/ Extremity Ratio

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  11. Toe In / Out (deg)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  12. Distance (cm)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  13. Ambulation Time (sec)

    Time frame: Change from baseline to 16 weeks

  14. Velocity (cm/sec)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  15. Mean Normalized Velocity

    Time frame: Change from baseline to16 weeks

    Measured during a 4m walk using a gaitrite mat

  16. Number of Steps

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  17. Cadence (Steps/Min)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  18. Step Time Differential (sec)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  19. Step Length Differential (cm)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  20. Cycle Time Differential (sec)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

Sponsors and collaborators

Lead sponsor

University of Glasgow

Other

Registry information

Official study title

The Effects of Krill Oil Supplementation on Adaptations in Muscle Strength, Function, Mass and Neuromuscular Function to a Pragmatic Home-based Resistance Exercise Intervention in Sedentary Older Adults: a Randomised Controlled Trial

Acronym: KOREA

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
May 22, 2023
Registry last updated
Mar 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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