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OpenTrials
Completed

NCT Number: NCT04048096

Krill Oil and Muscle in Older Adults

The aim of this study is to determine the effects of krill oil supplementation on muscle mass in function in older adults. Half of the participants will receive krill oil supplements and the other half a placebo.

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Key information

Conditions

Aging Atrophy Muscular Atrophy Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Sarcopenia Signs and Symptoms

Age range

65 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Stuart Robert Gray

Glasgow, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI less than 35kg/m2

Exclusion criteria

  • Diabetes
  • severe cardiovascular disease
  • seizure disorders
  • uncontrolled hypertension (>150/90mmHg at baseline measurement)
  • cancer or cancer that has been in remission <5 years
  • ambulatory impairments which would limit ability to perform assessments of muscle function
  • dementia
  • taking medication known to affect muscle (e.g. steroids)
  • have an implanted electronic device (e.g. pacemaker/defibrillator/insulin pump)
  • on anticoagulant therapy
  • allergies to seafood
  • regular consumption of more than 2 portions of oily fish per week.

Treatment and study plan

Krill oil

Dietary Supplement

Aker Biomarine Superba Krill Oil

Placebo

Dietary Supplement

Mixed vegetable oil

Primary outcomes

  1. Change in Muscle strength

    Time frame: Change from baseline to 6 months

    knee extensor muscle strength

Secondary outcomes

  1. Change in Grip strength

    Time frame: Change from baseline to 6 months

    Grip strength

  2. Change in Muscle thickness

    Time frame: Change from baseline to 6 months

    Vastus lateralis muscle thickness

  3. Change in Short performance physical battery test

    Time frame: Change from baseline to 6 months

    SPPB

  4. Change in Body Fat

    Time frame: Change from baseline to 6 months

    Measured by BIA

  5. Change in Lean Mass

    Time frame: Change from baseline to 6 months

    Measured by BIA

  6. Change in Fasting glucose

    Time frame: Change from baseline to 6 months

    Fasting glucose

  7. Change in Blood lipids

    Time frame: Change from baseline to 6 months

    Blood lipids

  8. Change in CRP

    Time frame: Change from baseline to 6 months

    CRP

  9. Change in Erythrocyte fatty acid profile

    Time frame: Change from baseline to 6 months

    Erythrocyte fatty acid profile

Sponsors and collaborators

Lead sponsor

University of Glasgow

Other

Registry information

Official study title

Effects of Krill Oil Supplementation on Muscle Function in Older Adults

Important dates

Study start
2018
Primary completion
2020
Study completion
2020
First posted
Aug 7, 2019
Registry last updated
Nov 3, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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