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Completed

NCT Number: NCT07210060

Knee Strengthening With Hip vs. Ankle Exercises in Women With Patellofemoral Pain Syndrome

Eight weeks of telehealth-based supervised exercise effectively reduced DKV and pain in women with anterior knee pain. Both intervention groups demonstrated comparable benefits.

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Key information

Age range

20 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Nai-Jen Chang

Tainan, Kaohsiung City, 807, Taiwan

About this study

This study compared the effects of knee strengthening combined with either hip or ankle joint exercises on dynamic knee valgus (DKV), visual analogue scale (VAS) scores during activity, tendon stiffness, muscle structure, ankle range of motion, and muscle strength in women with anterior knee pain. Forty-five female recreational athletes aged 20-40 with anterior knee pain were randomly assigned to three groups: hip + knee exercises (HK group, n = 15), ankle + knee exercises (AK group, n = 15), and stretching alone (control group, n = 15). The HK and AK groups received supervised telehealth-based exercise sessions (30 minutes/day, 3 times/week for 8 weeks), while the control group received only an educational pamphlet. Assessments were conducted at baseline, 4 weeks, and 8 weeks.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Female recreational athletes aged 20-40 years who engage in regular exercise
  • Experiencing pain in the anterior or surrounding patella during at least two or more of the following activities: walking, running, jumping, kneeling, squatting, climbing stairs, or prolonged sitting
  • A pain index of 3 or higher on the Numeric Pain Rating Scale (NPRS) and symptoms persisting for at least 3 months
  • Knee pain unrelated to trauma.

Exclusion criteria

  • Inability to operate a smartphone or computer
  • History of fractures or surgeries involving the hip, knee, ankle, or foot
  • History of meniscus, knee ligament injuries, or ankle sprains within the last six months
  • Knee ligament laxity, inflammation, swelling, patellar dislocation, or subluxation
  • Cognitive impairment or inability to follow simple instructions
  • History of cardiovascular or neurological disorders
  • Advised by a physician to avoid exercise. Use of over-the-counter pain medication was not an exclusion criterion.

Treatment and study plan

hip + knee joint exercise group

Other

Hip: squat, glute bridge and gluteus medius exercise Knee: knee flexor and extensor, isometric squat hold

ankle + knee joint exercise group

Other

Knee: knee flexor and extensor, isometric squat hold Ankle: plantar flexor, dorsi flexor and lunge

Stretching group

Other

Education Handout on Lower Limb Stretching

Primary outcomes

  1. Single Leg Landing Task

    Time frame: 2 minute

    The participant stood on a 30 cm box and first bent the non-testing leg's knee to approximately 90 degrees. After stabilizing, the participant jumped forward with the testing leg to a target 10 cm away from the box, maintaining balance for five seconds upon landing.

Secondary outcomes

  1. Numeric Pain Rating Scale

    Time frame: 1 minute

    0 indicates no pain and 10 indicates the worst pain imaginable.

  2. Patellar Tendon Stiffness Measurement

    Time frame: 3 minute

    The stiffness of the patellar tendon was assessed using a handheld device (MyotonPRO; Tallinn, Estonia).

  3. Muscle structure

    Time frame: 15 minute

    A portable ultrasound device (Linear wireless probe LU700L VET) was used to assess the structure of the gastrocnemius and gluteus medius muscles in a resting state.

  4. Ankle Joint ROM

    Time frame: 3 minute

    used a weight-bearing lunge test to measure the active dorsiflexion angle of the ankle during weight-bearing.

  5. Maximum Voluntary Isometric Strength

    Time frame: 15 minute

    A handheld dynamometer (MicroFET3; Hoggan Scientific LLC, USA) was used to measure the maximum isometric strength of the hip abductors, knee extensors, ankle dorsiflexors, and ankle plantar flexors.

Sponsors and collaborators

Lead sponsor

Kaohsiung Medical University Chung-Ho Memorial Hospital

Other

Registry information

Official study title

Comparison of Knee Strengthening Combined With Hip or Ankle Joint Exercises on Clinical Symptoms, Sports Performance and Soft Tissue Structure in Women With Patellofemoral Pain Syndrome

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Oct 7, 2025
Registry last updated
Oct 7, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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