Skip to main content
OpenTrials
Recruiting

NCT Number: NCT06863610

Knee Extension Deficit Following an Anterior Cruciate Ligament Reconstruction (Extension Loss)

Knee extension loss following an anterior cruciate ligament (ACL) reconstruction is believed to play an important role in quadriceps strength recovery. One of the main goals of the rehabilitation following ACL reconstruction is to restore knee extensor muscle strength. Deficits of more than a five-degree extension range of motion (ROM) could lead to delayed knee functionality and anterior knee pain. However, the effect of knee extension deficits in the early postoperative phase of the ACL reconstruction on knee extensor muscle strength recovery and knee functionality is not yet known.

This study aimed to investigate the difference between knee extensor muscle strength recovery and knee functionality in patients with ACL repair who had a knee extension ROM deficit (>5°) in the early postoperative period and those who did not.

Recruiting

Interested in participating?

Request Info

Key information

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hacettepe University, Faculty of Physical Therapy and Rehabilitation

Ankara, 06100, Turkey (Türkiye)

Location status: Recruiting

Location contact

Leyla ERASLAN, Prof

CONTACT

[email protected]

Volga Bayrakcı Tunay, Prof

CONTACT

About this study

Knee range of motion deficits are significant surgical complications following an anterior cruciate ligament (ACL) reconstruction, and despite current advances in surgical techniques, knee range of motion cannot always be regained. Previous studies reported that knee range of motion (ROM) deficits play an important role in knee extensor muscle weakness and knee osteoarthritis. Thus, deficits in knee extension joint motion are more difficult to tolerate than flexion deficits. It has been reported that a five-degree decrease in the extension ROM of the affected knee compared to the healthy side can lead to secondary complications such as difficulty walking and anterior knee pain. However, the effect of knee extension deficits in the early postoperative phase of the ACL reconstruction on knee extensor muscle strength recovery and knee functionality is not yet known.

This study aimed to investigate the difference between knee extensor muscle strength recovery and knee functionality in patients with ACL repair who had a knee extension ROM deficit (>5°) in the early postoperative period and those who did not.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who underwent ACL repair using hamstring tendon autograft
  • volunteered to participate in the study between the ages of 18-45
  • a non-contact injury mechanism
  • a Tegner Activity Score >5 before the injury
  • regularly attended the rehabilitation program after surgery (not missing more than three sessions)

Exclusion criteria

  • Patients who underwent ACL repair with patellar tendon autograft or allograft, revision surgery
  • underwent meniscus and or cartilage repair in addition to ACL repair
  • a history of previous knee, ankle, or groin injuries
  • concomitant systemic and/or neurological pathologies
  • a history of injury to the contralateral lower extremity
  • do not want to participate in the evaluations that should be done before the study.

Treatment and study plan

Extension Deficit (>5 degrees)

Other

Patients who had a knee extension ROM deficit of more than 5 degrees will included

Extension Deficit (<5 degrees)

Other

Patients who had a knee extension ROM deficit of less than 5 degrees will included

Primary outcomes

  1. Quadriceps Muscle Strength Recovery

    Time frame: Qudriceps muscle strength will be measured at 4th weeks (isometric), 12 th weeks (isometric and concentric), 6th months (isometric, concentric, and eccentric) following a surgery.

    Isometric, concentric and eccentric quadriceps muscle strength will be measured using an isokinetic dynamometer (IsoMed®2000 D&R GmbH, Germany).

  2. Hamstring Muscle Strength Recovery

    Time frame: Hamstring muscle strength will be measured at 4th weeks (isometric), 12 th weeks (isometric and concentric), 6th months (isometric, concentric, and eccentric) following a surgery.

    Isometric, concentric and eccentric hamstring muscle strength will be measured using an isokinetic dynamometer (IsoMed®2000 D&R GmbH, Germany).

Secondary outcomes

  1. The Y Balance Test. Functional Testing 1

    Time frame: Assessments will be conducted at 12th weeks and 6th months following a surgery

    The Y Balance Test will be used. Three repetitions will be conducted for each limb, and mean values were recorded in centimeters.

  2. The Vertical Jump Test. Functional Testing 2

    Time frame: Assessments will be conducted at 12th weeks and 6th months following a surgery

    The Vertical Jump Test will be used. Three repetitions will be conducted for each limb, and mean values were recorded in centimeters.

  3. The Single Leg Hop Test. Functional Testing 3

    Time frame: Assessments will be conducted at 12th weeks and 6th months following a surgery

    The Single Leg Hop Test will be used. Three repetitions will be conducted for each limb, and mean values were recorded in centimeters

  4. The Lysholm score. Patient-reported outcomes measures 1

    Time frame: Self-reported recovery will be recorded at 12th weeks and 6th months following a surgery

    The Lysholm score will be used to assess self-reported recovery. The Lysholm score is an eight-item questionnaire that evaluates patients following knee ligament injury. This is scored on a 100-point scale from 0 (worst symptoms) to 100 (best symptoms), with 25 points attributed to pain, 15 to locking, 10 to swelling, 25 to instability,10 to stair climbing and 5 points each to limping, use of a support and squatting.

  5. The International Knee Documentation Committee subjective knee form (IKDC). Patient-reported outcomes measures 2

    Time frame: Self-reported recovery will be recorded at 12th weeks and 6th months following a surgery

    The International Knee Documentation Committee subjective knee form (IKDC) will be used to assess self-reported recovery.

    IKDC subjective knee form contains 18 selected items designed to measure symptoms. Total IKDC score ranges from 0 to 100, with 100 indicating the absence of symptoms and higher levels of knee function.

Study contacts

Contact information is provided by the study sponsor or research team.

Leyla Eraslan, Ph. D.

CONTACT

[email protected]

+905348488373

Sponsors and collaborators

Lead sponsor

Hacettepe University

Other

Registry information

Official study title

Investigating the Knee Extension Deficit on Knee Strength Recovery Following an Anterior Cruciate Ligament Reconstruction

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Mar 7, 2025
Registry last updated
Sep 12, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.