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OpenTrials
Completed

NCT Number: NCT00855023

Knee Alignment Contributions to Anterior Cruciate Ligament (ACL) Injury

This study evaluates the the anatomic factors of the knee that may predispose to ACL injury.

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Key information

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Open MRI of Washington

Rockville, Maryland, 20850, United States

About this study

Despite intense study of anterior cruciate ligament injury during the past three decades, the mechanisms of this injury have not been clearly defined. A recent study by the Principle Investigator identified differences in leg alignment when a single leg landing during a sports activity resulted in a torn ACL and when it did not (provocative versus control alignment, respectively).

The purpose of the study is to quantify the tibiofemoral alignment in the lateral compartment of the knee in the provocative landing position and the control landing position. in order to elucidate possible mechanisms of ACL injury Material and Methods: 25 normal controls will be recruited from the greater Washington DC population. Magnetic resonance images in the sagittal plane will be acquired for a single leg of each subject. These images will cover the lateral compartment of the knee and will be acquired with the leg in three positions, one that emulates the injury position, one that exagerrates the injury position, and one that emulates the control landing position. Statistical analysis of the measurements between the provocative, exagerrated provocative, and control positions will then be performed.

These insights could then be applied to improving training focused on reducing the incidences of ACL rupture; improving bracing designs to help athletes most at risk of ACL rupture or those recovering from ACL injury/surgery; and improving ACL replacement surgeries.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy controls
  • Ages 18-45 years old

Exclusion criteria

  • Previous knee injury or surgery
  • Metal implants in body

Treatment and study plan

Primary outcomes

  1. Measurement of anatomy of knee

    Time frame: 1 hour

Sponsors and collaborators

Lead sponsor

The Orthopaedic Center, Maryland

Other

Registry information

Official study title

Tibiofemoral Alignment: Contributing Factors to Noncontact Anterior Cruciate Ligament Injury

Important dates

Study start
2007
Primary completion
2010
Study completion
2010
First posted
Mar 3, 2009
Registry last updated
Mar 18, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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