Kisspeptin/GPR54 Pathway and Early Puberty

There was a worldwide early trend in girls'age for puberty onset. The timing of puberty onset varies greatly among individuals, and much of this variation is modulated by genetic factors. This study was designed to explored the association of polymorphisms in KISS1/GPR54 pathway genes and the risk of early puberty in Chinese Han girls.

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Key information

Conditions

Puberty, Precocious Endocrine System Diseases Gonadal Disorders

Age range

7 year–10 year

Sex eligibility

Female

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Clinical diagnosis of central precocious puberty or early and fast puberty.

Exclusion criteria

The participants who were not the first visit to the hospital and had been treated before.
The participants who were with endocrine disorders.

Treatment and study plan

this study was an observational study and no interventions were given to the participants

Other

the participants were recruited and the data as well as blood sample were collected.

Primary outcomes

the polymorphism in the KISS1/GPR54 pathway genes

Time frame: 3 months

functional SNP loci of the KISS1/GPR54 pathway genes KISS1, KISSIR, PLCB1, PRKCA, and ITPR1 were selected and detected.

Sponsors and collaborators

Lead sponsor

Shenzhen Center for Disease Control and Prevention

Other Gov

Registry information

Official study title

Polymorphisms in the Kisspeptin/GPR54 Pathway Genes and the Risk of Early Puberty

Important dates

Study start: 2016
Primary completion: 2018
Study completion: 2019
First posted: Jul 9, 2019
Registry last updated: Jul 11, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed