Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease

Delivery of Interventions:

• Administration of a single kisspeptin bolus in a dosing range of 0.313 - 13.19 μg/kg
• Blood sampling before and after administration of kisspeptin (two timepoints total)

Inclusion criteria

• Female (ages 18-45 years) or Male (ages 18-60 years)
• No current or recent use of a medication (including hormonal replacement) that, in the opinion of a study investigator, can modulate the reproductive axis or willing to complete an appropriate washout for that particular medication and its method of administration
• For women, negative serum hCG pregnancy test
• For cases, diagnosis of post-covid-19 syndrome
• For controls, history of prior covid infection but no diagnosis of post-covid-19 syndrome

Exclusion criteria

• Any condition (medical, mental, or behavioral) that, in the opinion of a study investigator, would likely interfere with participation in/completion of the protocol or the interpretation of results
• Active use of illicit drugs (not including marijuana)
• For women,
• Pregnant
• Trying to become pregnant during protocol participation
• Breast feeding
• Surgical or natural menopause