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Completed

NCT Number: NCT06008600

KINO-DYSPNEA: Validation of Kinocardiography to Distinguish Dyspnea of Cardiac Origin From Others

Seismocardiography (SCG) measures the thoracic vibrations caused by the cardiac contraction and ejection of blood into the great vessels. Current smartphones with gyroscopes and accelerometers can measure these vibrations. Based on these components we measure and quantify the cardiac kinetic energy (kinocardiography) in order to differentiate dyspnea of cardiac origin from dyspnea of other origin. The study is conducted in an emergency service where a smartphone performs the measurement during 3 minutes. The results of the kinocardiography-based classification are then compared to the final diagnosis made by a physician. Currently, 235 patients have been included in the clinical study since May 2022. This rapid and non-invasive measurement allows the aid-to-diagnosis of heart failure without being influenced by other factors like the renal function for example that can be NT-pro BNP blood marker.

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Key information

Conditions

Dyspnea Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Tract Diseases Signs and Symptoms Signs and Symptoms, Respiratory

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU Tivoli

La Louvière, Hainaut, 7100, Belgium

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Dyspnea.
  • Adults aged above 18 years old.

Exclusion criteria

  • Patients younger than 18 years old.

Treatment and study plan

Kinocardiography

Device

Smartphone (application with seismocardiography)

Other names: NT-pro BNP blood measurement

Primary outcomes

  1. Evaluate the ability of the Kinocardiography technique to discriminate cardiac caused dyspnea from others.

    Time frame: 18 months

    Area under the receiver operating characteristic curve (AUROC), negative predictive value (NPV) and specificity, with two-sided 95% CIs.

Secondary outcomes

  1. Open retrospective exploratory study to validate the physiological interpretation of Kinocardiography in a clinical environment.

    Time frame: 18 months

    Establish a link between cardiac kinetic energy distribution in the cardiac cycle between major active clinical syndromes that may be concomitant in the field of cardiac disorders (hypertension, atrial fibrillation, ischemia, valvulopathy, heart-failure,…) and pulmonary (asthma, infection,..). These clinical diagnoses are supported by the physical examination and the patient's medical record at inclusion, with the aid of a measurement of troponin and NTBNP

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Tivoli

Other

Collaborators

  • HeartKinetics

Registry information

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Aug 23, 2023
Registry last updated
Jan 22, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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