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OpenTrials
Completed

NCT Number: NCT02860260

Kinetics of Plasma and Serum Levels of Brain-Derived Neurotrophic Factor (BDNF) in Patients With Ischemic Stroke

The aim of this study is to show for the first time that treatment with intravenous fibrinolysis using rt-PA in patients with recent ischemic stroke is accompanied by increases in circulating levels of BDNF, which may reflect an increase in BDNF synthesis in the brain.

The analysis of the recovery of functional and cognitive abilities as well as mood at 3 months will allow us to study the impact of BDNF on these parameters. Thus, depending on the results obtained, circulating BDNF could serve as an early marker of these.

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Key information

Conditions

Ischemic Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Nervous System Diseases Stroke Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Centre Hospitalier Universitaire

Dijon, 21079, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients (or their person of trust in cases of inability) who have been informed about the research and given their consent to take part
  • Patients aged 18 years or older
  • Patients who have suffered a de novo recent ischemic stroke < 12 hours
  • Patients who had cerebral imaging (CT-Scan or MRI)
  • Ischemic stroke severity, measured by the National Institute of Health Stroke Score (NIHSS), between 4 and 20

Exclusion criteria

Patients without national health insurance cover

  • Patients with a clinical history of stroke
  • Patients with cerebral or sub-arachnoid haemorrhage
  • Patients with a transient ischemic attack
  • Time of symptom onset unknown
  • Patients with severe aphasia at the time of the ischemic stroke defined by a sub-score for item 9 (best language) of the NIHSS ≥ 2
  • Patients with dementia prior to the ischemic stroke
  • Patients with a significant loss of autonomy prior to the ischemic stroke, defined by a Rankin score ≥ 4
  • Patients with aphasia before the ischemic stroke
  • Patients with a contra-indication for cerebral MRI
  • Pregnant or breast-feeding women
  • Adults under guardianship
  • Subjects in custody
  • Patients who do not speak French

Treatment and study plan

blood samples

Biological

cerebral MRI

Other

Primary outcomes

  1. Measurement of plasma levels of BDNF

    Time frame: Change from baseline at Day1, Day 7 and Month 3

  2. Measurement of serum levels of BDNF

    Time frame: Change from baseline at Day1, Day 7 and Month 3

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire Dijon

Other

Registry information

Official study title

Kinetics of Plasma and Serum Levels of Brain-Derived Neurotrophic Factor (BDNF) in Patients With Ischemic Stroke: Effect of Intravenous Fibrinolysis With Rt-PA

Acronym: BDNF

Important dates

Study start
2011
Primary completion
2012
First posted
Aug 9, 2016
Registry last updated
Mar 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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