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NCT Number: NCT07417748

Kinesthetic Exercises on Adults

The aim of this study is to determine the possible effect of kinesthetic brain exercises on cognitive function in patients with heart failure.

The study will include 40 volunteer individuals aged 30-65 years who have been diagnosed with heart failure in the Cardiology Department and are followed up with a physiotherapy program. Individuals will be randomized into a kinesthetic brain exercise program group (n=20) and a control group (n=20).

The control group will receive routine medication monitoring as well as a routine physiotherapy program. The education group will receive routine medication monitoring and a routine physiotherapy program, in addition to individual kinesthetic brain exercise training. Kinesthetic brain exercises will be performed for 30 minutes, 2 days a week for 8 weeks. Demographic information of the individuals will be collected; age, gender, body mass index, age at diagnosis, ejection fraction ratio, family history, smoking status (years/pack). Cognitive function; The Montreal Cognitive Assessment Scale (MoCA), quality of life using the Minnesota Heart Failure Living Questionnaire, and cognitive performance using the Standardized Minimental Test (SMMT) will be used for evaluation. Biochemical analyses will be performed using the Brain-Derived Neurotrophic Factor (BDNF) ELISA kit. Patients in both groups will be evaluated by a physiotherapist before the study and at week 8.

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Key information

Conditions

Heart Cardiovascular Diseases Heart Diseases Heart Failure

Age range

30 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ege University

Izmir, Karsiyaka, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosed with heart failure
  • Between 30-65 years of age
  • No history of cardiac surgery
  • Cooperative patients

Exclusion criteria

  • Diagnosed with or having a history of neurological disease
  • Pregnant or suspected of being pregnant
  • Scoring above 24 on the Mini Mental Test
  • Patients for whom exercise is contraindicated
  • Individuals with a history of orthopedic surgery

Treatment and study plan

Kinesthetic brain exercises

Other

Kinesthetic brain exercises are a series of movements designed to connect the body and mind, encourage the use of brain hemispheres through physical and mental strategies, and also improve and strengthen cognitive functions for learning.

Cardiorespiratory Physiotherapy

Other

This is the standard physiotherapy procedure applied to patients with heart failure. It includes practices aimed at improving breathing, improving respiratory muscle strength, and providing mobilization. It encompasses breathing exercises, functional mobility exercises, stretching and flexibility exercises for the upper and lower extremities, etc.

Heart Failure drugs

Drug

Continued use of medications prescribed by the cardiologist, under the supervision of the doctor.

Primary outcomes

  1. Cognitive Function

    Time frame: Initially and after 8 weeks

    Cognitive function will be assessed using the Montreal Cognitive Assessment Scale (MoCA). The MoCA was developed as a rapid screening test for mild cognitive impairment. The MoCA assesses various cognitive functions, including attention and concentration, executive functions, memory, language, visual construction skills, abstract thinking, calculation, and orientation. The test is scored between 0 and 30 points. A score of 21 or higher is considered normal.

  2. Biochemical analyses

    Time frame: Initially and after 8 weeks

    Brain-derived neurotrophic factor (BDNF) will be examined through biochemical analyses.

  3. Cognitive Performance

    Time frame: Initially and after 8 weeks

    The Standardized Mini-Mental Test (SMMT) will be used to assess cognitive performance. Test scores range from 0 to 30. The threshold for the Mini-Mental Test is 22-23 for educated individuals and 18-19 for uneducated individuals. In assessments for individuals with dementia, scores between 25-30 indicate normal cognitive function, 21-24 indicate mild dementia, 10-20 indicate mild-to-moderate dementia, and 0-9 indicate advanced dementia.

Secondary outcomes

  1. Quality of life in heart failure

    Time frame: Initially and after 8 weeks

    Quality of life in heart failure will be assessed using the Minnesota Heart Failure and Life Questionnaire. This scale consists of 21 statements that specifically examine the quality of life in individuals with heart failure in terms of physical and emotional functioning. The sum of the answers to all 21 statements gives a total score ranging from 0 to 105. A lower score indicates a better quality of life.

Sponsors and collaborators

Lead sponsor

Ege University

Other

Registry information

Official study title

The Effect of Kinesthetic Brain Exercises on Cognitive Function in Patients With Heart Failure

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Feb 18, 2026
Registry last updated
Feb 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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