Kidney Biomarkers of Acute Kidney Injury in Patients With Knee Arthroplasty

Sensitive renal markers have been studied abundantly in connection with open heart, liver and transplantation surgery; however in major orthopaedic surgery their use is anecdotal. The aim of the present study is to evaluate use of sensitive renal markers, NGAL (Neutrophil gelatinase associated lipocalin ), KIM-1 (Kidney injury molecule- 1), LFABP (liver-type fatty acid-binding protein), and IL-18 (interleukin -18), in patients coming for elective TKA (total knee arthroplasty) as a pilot study before large study concerning acute kidney injury in orthopaedic surgery.

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Key information

Conditions

Arthroplasty, Replacement, Knee Acute Kidney Injury Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

50 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Kuopio University Hospital

Kuopio, Northern Savonia, 70029, Finland

About this study

Acute renal deterioration is a serious adverse event in elective surgery. Serum creatinine based diagnostics of acute kidney injury may delay diagnosis and produce false negative results since serum creatinine is affected by diet, muscle mass, used hydration therapy. In recent times new markers have been developed and tested in order to find sensitive, fast and reliable marker of renal deterioration.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

informed consent
allergy to NSAIDs

Exclusion criteria

no informed consent

Treatment and study plan

Primary outcomes

Renal function

Time frame: time zero hours to 48 hours

S-creatinine, Cystatin C, estimated GFR

Secondary outcomes

Concentraton of sensitive renal markers

Time frame: time zero hours to 24 hours

U-NGAL, P-NGAL, U-KIM-1, U-IL-18

Sponsors and collaborators

Lead sponsor

Kuopio University Hospital

Other

Registry information

Official study title

Kidney Biomarkers of Acute Kidney Injury in Patients With Knee Arthroplasty- a Pilot Study

Acronym: dexpolvi

Important dates

Study start: 2013
Primary completion: 2015
Study completion: 2015
First posted: Dec 30, 2015
Registry last updated: Feb 27, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed