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Completed

NCT Number: NCT00224588

KETOR: Effects of Peri Operative Administration of Ketamine on Long Term Post Thoracotomy Pain

We assessed the effects of the N Methyl aspartate receptor antagonist Ketamine on long-term post thoracotomy pain. We hypothesized that ketamine could prevent supersensitization of the central nervous system involved in this chronic neuropathic pain.

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Key information

Conditions

Ketamine Chronic Post Thoracotomy Pain Nervous System Diseases Neuralgia Neurologic Manifestations Neuromuscular Diseases Pain Pathological Conditions, Signs and Symptoms Peripheral Nervous System Diseases Signs and Symptoms Thoracotomy

Age range

80 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

Georges Pompidou European Hospital

Paris, Île-de-France Region, 75015, France

About this study

In this clinical, randomized prospective study, peri operative administration of ketamine was compared to placebo on long term post thoracotomy pain after a 2 months follow up period.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients eligible for thoracotomy or pneumectomy

Exclusion criteria

-

Treatment and study plan

Ketamine (or placebo : isotonic saline solution)

Drug

Primary outcomes

  1. Long term (2 months) post thoracotomy pain was assessed using a french equivalent of the Mc Gill Pain score and pain area measurements in both groups

Secondary outcomes

  1. Analogic pain scores at rest and after coughing

Sponsors and collaborators

Lead sponsor

Assistance Publique - Hôpitaux de Paris

Other

Collaborators

  • Clinical Research Unit
  • Direction Régionale de la Recherche Clinique D'ILE DE FRANCE
  • European Georges Pompidou Hospital

Registry information

Official study title

Effects of Peri Operative Administration of Ketamine on Long Term Post Thoracotomy Pain

Important dates

Study start
2003
Study completion
2005
First posted
Sep 23, 2005
Registry last updated
Apr 13, 2006

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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