Ketone Supplementation in Eating Disorders

The goals of the study are:

• to test the effect of BHB as a nutritional supplement for AN and BN and 2) to test the ingestion of BHB on brain function.

Subjects will complete a battery of self-assessments and a diagnostic assessment in order to determine eligibility and for characterization of behavior to be used in later analyses. After eligibility is confirmed, subjects will complete 2 EEG scans on separate days after ingestion of Ketone supplement drink or placebo and will complete a taste reward task during the EEG scan. Subjects will then complete 2 weeks of daily ketone supplementation and self-assessments.

Inclusion criteria

• Must currently meet DSM-5 criteria for Anorexia Nervosa, Bulimia Nervosa, or OSFED Anorexia or Bulimia Nervosa based on the MINI diagnostic interview
• Be medically stable as assessed by a comprehensive medical and behavioral evaluation conducted by a study physician
• English as primary spoken language.
• Ability to respond to EMA questions up to 6x per day within 60 minutes of receiving the message.

Exclusion criteria

• Psychotic illness/other organic brain syndromes, dementia, somatization disorders or conversion disorders
• Current substance abuse or dependence in the past 3 months
• Physical conditions (e.g., diabetes mellitus, pregnancy) known to influence eating or weight
• Medical conditions associated with ketoacidosis: type 1 diabetes mellitus, acute pancreatitis, alcoholic gastritis, peptic ulcer disease, hepatitis or Boerhaave syndrome (esophageal rupture)
• History of significant head trauma
• Indication of intellectual disability or autism spectrum disorder
• Known allergy to any of the KenetikR drink components: D-beta-hydroxybutyric acid (D-BHB), Stevia, Monkfruit, Potassium Bicarbonate, Sodium Bicarbonate Potassium Sorbate or Taste Task Solutions: Sucrose, Potassium Chloride, Sodium bicarbonate.