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Completed

NCT Number: NCT00797264

Ketamine Associated With Morphine PCA After Total Hip Arthroplasty

Ketamine (an analgesic drug often associated with morphine in the treatment of Opioid Induced Hyperalgesia) is often mixed in Morphine PCA syringe. We make the hypothesis that ketamine administrated separately via a continuous infusion, could induced a better analgesic effect.

We will perform a randomised double blind study to determine the best infusion mode of intravenous ketamine, associated with morphine in PCA syringe or alone in continuous infusion.

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Key information

Conditions

Arthroplasty, Replacement, Hip Hyperalgesia Nervous System Diseases Neurologic Manifestations Pathological Conditions, Signs and Symptoms Sensation Disorders Signs and Symptoms Somatosensory Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Service d'anesthesie-reanimation - Hôpital Bicêtre

Le Kremlin-Bicêtre, 94270, France

About this study

Double blind study to determine the best infusion mode of intravenous ketamine, associated with morphine in PCA syringe or alone in continuous infusion

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • total hip arthroplasty

Exclusion criteria

  • pre operative opioid administration

Treatment and study plan

Ketamine-Morphine

Drug

Ketamine bolus preoperative and syringe pump peroperative, and morphine postoperative (PCA)

Other names: Ketamine pre and per operative, and morphine postoperative

Morphine

Drug

Bolus preoperative of NaCl and syringe pump peroperative of NaCl, and morphine postoperative (PCA)

Postoperative PCA of Ketamine and morphine

Drug

Bolus preoperative of NaCl and syringe pump peroperative of Ketamine, and morphine postoperative (PCA)

Other names: Ketamine Morphine

Primary outcomes

  1. Morphine consumption in PACU and in hospitalisation room

    Time frame: at 24 and 48 hours

Secondary outcomes

  1. Postoperative Visual Analogic Score of pain

    Time frame: in Recovery Room, at 24 and 48 hours, in the ward

  2. Postoperative Measure of mechanical hyperalgesia by Von Frey filament device

    Time frame: 24 and 48 hours in the ward

  3. Postoperative measure Ketamine and Nor-Ketamine blood levels

    Time frame: at 24 and 48 hours in the ward

Sponsors and collaborators

Lead sponsor

Assistance Publique - Hôpitaux de Paris

Other

Registry information

Official study title

Impact of the Route of Administration of Ketamine Associated With Morphine PCA on Analgesia After Total Hip Arthroplasty

Acronym: KETAMINE

Important dates

Study start
2008
Primary completion
2010
Study completion
2010
First posted
Nov 25, 2008
Registry last updated
Apr 11, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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