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NCT Number: NCT05268562

Ketamine and Kidney Injury in Cardiac Surgery

The purpose of this study is to investigate the affects of ketamine use for anesthesia at the beginning of heart surgery on kidneys compared to the use of propofol.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Cardiac Surgery

Age range

70 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Presenting for cardiac surgery at the Mayo Clinic in Rochester, Minnesota.
  • Scheduled to undergo complex cardiac surgery with the use of cardiopulmonary bypass. Complex cardiac surgery will be defined as surgery involving more than one heart valve, redo-sternotomy procedures, or combined valvular and coronary artery bypass graft procedures (aortic repair not excluded if meets other criteria).

Exclusion criteria

  • Left or right ventricular assist device implantation or explantation.
  • Procedures not requiring cardiopulmonary bypass.
  • Active infection or sepsis requiring antimicrobial therapy and/or vasopressor therapy (treated endocarditis is not excluded).
  • Severe hepatic disease resulting in ascites.
  • Pre-operative significant renal dysfunction including a baseline creatinine equal to or greater than 2 mg/dL or requiring dialysis.
  • Immunosuppressive medication use (including current IV or oral steroids use, use of anti-rejection medications for transplant within 1 month, or chemotherapy within 6 months).
  • Immunodeficiency syndrome including HIV/AIDS, leukemia, and multiple myeloma

Treatment and study plan

ketamine

Drug

1-2 mg/kg induction with additional medication administered as needed to achieve intubating conditions

Propofol

Drug

0.5-1 mg/kg induction with additional medication administered as needed to achieve intubating conditions

Primary outcomes

  1. Acute Kidney Injury

    Time frame: Immediately postop up to 10 days postoperatively

    The incidence of acute kidney injury in patients following cardiac surgery

Secondary outcomes

  1. Vasopressor use

    Time frame: Immediately post induction up to 30 minute following induction

    Compare mean total vasopressor doses, in norepinephrine equivalents, between groups following induction as a surrogate for hemodynamic differences

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Official study title

Impact of Ketamine Versus Propofol for Anesthetic Induction on Acute Kidney Injury and Renal Biomarkers in Cardiac Surgery

Important dates

Study start
2022
Primary completion
2025
Study completion
2027
First posted
Mar 7, 2022
Registry last updated
Jul 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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