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OpenTrials
Completed

NCT Number: NCT02891655

KERatoconus and Metalloproteinases InvesTigation

Corneal stromal thinning observed in keratoconic eyes could result from an increased synthesis of MMP at the level of the anterior stroma and the corneal epithelium induced by an overexpression of the Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) and Galectin-3 by epithelial cells. A differential expression of EMMPRIN, Galectin-3 and metalloproteinases (MMP) may be observed between the apex of the keratoconus and the peripheral cornea. Highlighting the implication of EMMPRIN and Galectin-3 could lead to the development of specific inhibitors to slow or to stop keratoconus evolution.

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Key information

Conditions

Keratoconus Corneal Diseases Eye Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Fondation Opthalmologique A de Rothschild

Paris, 75019, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age > 18 years old
  • Patient with keratoconus undergoing corneal collagen cross-linking (epithelium-off methods)
  • Patient with keratoconus undergoing his first corneal graft for optical indication (control)

Exclusion criteria

  • Patient with keratoconus undergoing corneal graft for tectonic indication
  • Patient undergoing corneal refractive surgery (refractive photokeratectomy) with a normal topography, a normal slit lamp examination and no previous ophthalmic condition (control)
  • pregnant or breast feeding patient
  • patient under judiciary protection
  • patient opposition to participate in the study

Treatment and study plan

immuno-histo-chemical analysis

Other

in vitro immuno-histo-chemical analysis of corneal epithelium

Primary outcomes

  1. expression of the Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) in epithelial cells

    Time frame: baseline

Sponsors and collaborators

Lead sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Network

Registry information

Acronym: KERMIT

Important dates

Study start
2016
Primary completion
2020
Study completion
2020
First posted
Sep 7, 2016
Registry last updated
Dec 10, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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