Faculty of Dental Medicine for Girls, Al-Azhar University
Cairo, Cairo Governorate, Egypt
Completed
NCT Number: NCT07156799
Kaempferol Gel , Alkaline Phosphatase Activity , Bone Density Around Dental Implants
Kaempferol gel was tested as a local adjunct during implant placement in 30 patients. Compared to controls, the Kaempferol group showed significantly higher ALP activity at 2 and 4 weeks and greater bone density gain after 6 months (40.73% vs. 33.21%). These findings suggest Kaempferol enhances early bone remodeling, improves peri-implant bone quality, and may allow earlier implant loading.
Completed
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Notify MeKey information
Age range
18 year–50 year
Sex eligibility
All sexes
Study type
Interventional
Phase
Not applicable
Primary location
About this study
This randomized controlled clinical trial investigated the effect of Kaempferol gel, a natural antioxidant and bone-healing compound, on dental implant healing in the maxillary posterior region. Thirty patients were divided into two groups: one received Kaempferol gel during implant placement, while the other did not.
The study measured alkaline phosphatase (ALP) activity in peri-implant crevicular fluid at 1, 2, and 4 weeks, and bone density using CBCT at baseline and 6 months. Results showed that Kaempferol significantly boosted ALP activity at 2 and 4 weeks, suggesting faster bone remodeling. At 6 months, bone density improved in both groups, but the Kaempferol group showed a greater increase (40.73% vs. 33.21%).
In conclusion, Kaempferol gel enhanced early bone healing and improved bone density around implants, indicating its potential as a cost-effective, biocompatible adjunct to accelerate osseointegration and possibly allow earlier implant loading, particularly in patients with poor bone quality.
Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- At least one missing maxillary posterior tooth with a healed ridge
Exclusion criteria
- Previous bone grafting at the implant site.
Treatment and study plan
Kaempferol Gel
DrugLocal topical application of Kaempferol gel into the implant site during one-stage delayed implant placement to enhance peri-implant bone healing and osseointegration.
Other names: Flavinoids
Primary outcomes
-
alkaline phosphatase level
Time frame: at baseline, 1,2, 4 weeks
Change in alkaline phosphatase (ALP) activity measured in peri-implant crevicular fluid (PICF) using ELISA to evaluate early bone remodeling activity.
Secondary outcomes
-
Bone density around implants
Time frame: Baseline and 6 months postoperatively
Change in peri-implant bone density assessed by cone beam computed tomography (CBCT) at the implant site
Sponsors and collaborators
Lead sponsor
Al-Azhar University
Other
Registry information
Official study title
Influence of Kaempferol Gel on Alkaline Phosphatase Activity and Bone Density Around Dental Implants: A Randomized Controlled Clinical Trial
Important dates
- Study start
- 2023
- Primary completion
- 2024
- Study completion
- 2024
- First posted
- Sep 5, 2025
- Registry last updated
- Sep 5, 2025
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.