Japan Morning Surge-1 Study

The purpose of this study is to examine whether strict blood pressure (BP) control by doxazosin using home BP monitoring, especially targeting the morning BP level, can reduce hypertensive target organ damage.

Completed

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Key information

Conditions

Hypertension Cardiovascular Diseases Vascular Diseases

Age range

0 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine

Shimotsuke, Tochigi, 329-0498, Japan

About this study

Morning blood pressure may play an important role in the pathogenesis of hypertensive target organ damage. Increased sympathetic nerve activity is reported to be one of the mechanisms of morning hypertension; however, there are no available data that show whether strict home blood pressure control, especially in the morning period, can reduce target organ damage.We will evaluate whether strict morning blood pressure control by sympathetic nervous system blockade using an alfa-blocker, doxazosin, and with the addition of a beta-blocker if needed, can reduce hypertensive target organ damage.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Morning systolic blood pressure >135 mmHg in a sitting position at home while on stable antihypertensive medication for at least 3 months

Exclusion criteria

History of heart failure
Presence of orthostatic hypotension, dementia, malignancy and chronic inflammatory disease
Taking an alfa-blocker or beta-blocker
Atrial fibrillation or atrial flutter

Treatment and study plan

Doxazosin (drug)

Drug

Primary outcomes

brain natriuretic peptide and the urinary albumin excretion/creatinine ratio at 6 months

Sponsors and collaborators

Lead sponsor

Japan Heart Foundation

Other

Registry information

Official study title

The Effects of Controlling Morning Hypertension on Target Organ Damage With Adrenergic Blockers, Based on Self-Measured Morning Blood Pressure Readings

Important dates

Study start: 2003
Study completion: 2005
First posted: Feb 2, 2006
Registry last updated: Feb 2, 2006

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed