Janus Kinase 1 in Vitiligo & Psoriasis

Assessment of the level of JAK1 in both vitiligo and psoriasis patients before and after treatment with NB-UVB which is considered a gold standard therapy for both diseases.

Completed

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Key information

Conditions

Vitiligo Hypopigmentation Pigmentation Disorders Skin Diseases Skin and Connective Tissue Diseases

Age range

12 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

age above 12 years of age.
psoriasis vulgaris or non-segmental vitiligo
patients who received no systemic or topical treatment at least 6 weeks prior to enrollment into the study.

Exclusion criteria

psoriasis patients with erythrodermic psoriasis, pustular psoriasis or associated psoriatic arthritis
vitiligo patients with segmental or universal vitiligo were excluded from the study.
any patient with a photosensitive disorder or any contraindication to phototherapy exposure, e.g., history or presence of malignant or premalignant skin lesions.

Treatment and study plan

Skin biopsy

Other

Two (4 mm) punch skin biopsies were taken from the 20 patients; one prior to the initiation of phototherapy and the other after the last session (from the same site). One skin biopsy was taken from the skin of each of the 10 control healthy participants. Skin biopsy specimens were preserved in Radio-Immunoprecipitation Assay (RIBA) buffer.

Primary outcomes

Measurement of the tissue level of JAK1 in both vitiligo and psoriasis patients before and after treatment with NB-UVB

Time frame: 1 year

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Expression of Janus Kinase 1 in Vitiligo and Psoriasis Before and After Narrow Band UVB: a Case-Control Study

Important dates

Study start: 2015
Primary completion: 2016
Study completion: 2016
First posted: Dec 3, 2018
Registry last updated: Dec 3, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed