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Completed

NCT Number: NCT05679375

IV and Intrathecal Ketamine in Cesarean Section

In the current study, the investigators will compare the effects of low-dose intravenous (i.v.) ketamine versus intrathecal Ketamine added to spinal anesthesia on the time to first request for analgesia and maternal pain scores and overall satisfaction in patients undergoing cesarean section.

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Key information

Conditions

Cesarean Section Agnosia Analgesia Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Perceptual Disorders Signs and Symptoms

Age range

18 year–45 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

Assiut university

Asyut, Egypt

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Pregnant undergoing elective cesarean section

Exclusion criteria

  • Significant coexisting diseases (pregnancy-induced hypertension or diabetes)
  • body mass index ≥40kg/m2, height <150cm
  • Current use of pain medication including opioids
  • history of substance abuse or hallucinations, cardiovascular disease, diabetes, multiple gestations
  • chronic pain was excluded.
  • contraindications to spinal anaesthesia,
  • severely compromised fetus requiring general anesthesia and those patients who received labor analgesia

Treatment and study plan

intrathecal ketamine

Drug

Patients will receive intrathecal Ketamine 0.1mg/kg added to bupivacaine and morphine

Intravenous ketamine

Drug

Patients will receive IV Ketamine 0.25mg/kg after spinal

Primary outcomes

  1. Time to the first analgesic request

    Time frame: First Postoperative day

Secondary outcomes

  1. Postoperative pain scores NRS at rest and on movement; (2, 4, 6, 12, and 24 hours) postoperative

    Time frame: first postoperative day

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Comparison Between the Analgesic Effects of Intrathecal Versus Intravenous Ketamine After Spinal Anaesthesia for Elective Caesarean Delivery :a Randomised Trial

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Jan 11, 2023
Registry last updated
Mar 6, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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