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NCT Number: NCT07445412

Italian Group of Regenerative and Occlusive Worldwide-used Techniques of Hepatic Hypertrophy

The goal of this national mutlticenter observational study is to learn and describe trends over time in the use of techniques for inducing hepatic hypertrophy in Italy. Patients will be treated according to the current clinical practice of the participating centers and will be observed from the moment of recruitment and throughout their stay. Information on vital status will be collected, as far as possible, for up to 5 years after surgery in order to record any events that occur in a timely manner. There are also plans to retrospectively collect data on patients who underwent hypertrophic techniques in the previous 10 years, in order to establish a historical cohort for each center that can be used for comparison with the prospective cohort.

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Key information

Conditions

Liver Tumours Adenocarcinoma Carcinoma Carcinoma, Hepatocellular Digestive System Diseases Digestive System Neoplasms Liver Cancer (Primary and Metastatic) Liver Diseases Liver Hypertrophy Liver Neoplasms Liver Resection Neoplasm Metastasis Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial Neoplastic Processes Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 18 or older
  • Obtaining informed consent
  • Patients with liver neoplasia (benign or malignant) and with a future liver remnant volume deemed insufficient (<20%-40%) by the local multidisciplinary team

Exclusion criteria

  • pregnant or breastfeeding woman

Treatment and study plan

Primary outcomes

  1. Describe the temporal trends in the use of techniques for inducing hepatic hypertrophy in Italy

    Time frame: through study completion, an average of 1 year

  2. compare the techniques used in terms of function and volumetric hypertrophy

    Time frame: through study completion, an average of 1 year

  3. compare the techniques used in terms of drop-out

    Time frame: through study completion, an average of 1 year

  4. compare the techniques used in terms of 90-day mortality

    Time frame: through study completion, an average of 1 year

  5. compare the techniques used in terms of long-term survival

    Time frame: through study completion, an average of 1 year

  6. compare the techniques used in terms of disease-free survival

    Time frame: through study completion, an average of 1 year

Study contacts

Contact information is provided by the study sponsor or research team.

Elio Jovine, MD

CONTACT

[email protected]

+39 3356468200

Matteo Serenari, MD

CONTACT

[email protected]

+39 3289277643

Sponsors and collaborators

Lead sponsor

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Other

Registry information

Official study title

Italian Group of Regenerative and Occlusive Worldwide-used Techniques of Hepatic Hypertrophy - IGROWtoh

Acronym: I-GROWtoh

Important dates

Study start
2024
Primary completion
2039
Study completion
2040
First posted
Mar 3, 2026
Registry last updated
Mar 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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