It is an Observational Study That Compare Prognosis of Typical and Atypical Systemic Lupus Erythematosus Presentation

Inclusion criteria

Patients diagnosed as SLE according toSLICC 2012Classification Criteria[13] :

A. Patients presented with typical lupus presentation:

• age of onset (20-50)
• common initial manifestations as constitutional manifestations,arthritis, mucocutaneousmanifestationslike malar rash, photosensitivity and hair falling.
• patients with ANA positive.

B. Patients presented with atypical lupus presentation:

• any clinical presentation not belonging to classic common SLE onset features, including but not limited to:

• Neuropsychiatric onset: seizure, psychosis, aseptic meningitis, transverse myelitis
• Cardiopulmonary onset: pulmonary hypertension, acute pneumonitis, myocarditis, pulmonary hemorrhage
• Gastrointestinal onset: mesenteric vasculitis, intestinal pseudo obstruction, pancreatitis
• Hematologic severe onset: isolated severe thrombocytopenia, autoimmune hemolytic anemia, thrombotic microangiopathy
• Dermatologic atypical onset: bullous lupus, panniculitis, vasculitic ulcers
• Myositis
• Fever of unknown origin (FUO) as sole initial presentation
• Thrombotic events
• Generalized lymphadenopathy.
• Patients with dominant organ affection.
• patients with late onset SLE.
• patients with ANA negative SLE. C.Patients who can provide informed consent.

Exclusion criteria

• Patients whose initial symptoms are clearly attributable to infection, sepsis or another non-SLE condition.
• Patients with chronic pre-existing diseases that may mimic or obscure the initial SLE presentation (e.g. primary epilepsy, primary pulmonary hypertension, chronic liver or GI disease).
• Patients in whom onset features cannot be reliably classified as typical or atypical due to mixed or unclear presentation.

Exclusion criteria

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