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Completed

NCT Number: NCT02458443

Isometric Handgrip Exercise for Blood Pressure Management

Recent meta-analyses suggest isometric resistance training (IRT) may be superior to aerobic exercise for lowering blood pressure. The investigators intend to conduct the largest, longest, prospective, double-blind randomized controlled trial using isometric resistance training to reduce blood pressure to reduce hypertension.

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Key information

Conditions

Hypertension Cardiovascular Diseases Vascular Diseases

Age range

30 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

UNE Exercise Physiology Lab

Armidale, New South Wales, 2351, Australia

About this study

We are looking to assess the effect of isometric exercise on ambulatory blood pressure in participants aged 40-70 years who are either pre- or mild hypertensive; either un-medicated or taking medication to control their blood pressure. Our secondary aims are to examine whether the size of blood pressure change is different in those people taking or not taking anti-hypertensive medication, to determine the anti-hypertensive mechanism to IRT, and to establish rate of de-training effects after participants have ceased IRT.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Blood pressure above 120/80 currently not taking anti-hypertensive medications whose doctor has suggested would benefit from exercise; and
  • people currently taking beta blockers for blood pressure management.

Exclusion criteria

  • Younger than 30yrs and older than 70 yrs;
  • unable to voluntary participate;
  • unable to participate under doctor's recommendation;
  • smokers;
  • arthritis or carpal tunnel which may be aggravated with handgrip exercise;
  • known cardiovascular disease (angina) and the following co-morbid conditions:
  • obesity,
  • insulin resistance,
  • depression,
  • mobility impairment,
  • sleep apnoea,
  • fatty liver disease or
  • renal disease

Treatment and study plan

Isometric resistance training

Other

Isometric handgrip exercise using a hand dynamometer

Primary outcomes

  1. Change in systolic and diastolic blood pressure

    Time frame: Change measures: baseline and 12 weeks

Secondary outcomes

  1. Compare and contrast change in systolic and diastolic blood pressure of medicated and un-medicated participants

    Time frame: Baseline and 12 weeks

  2. Detraining effects, changes in systolic and diastolic blood pressure after cessation of Isometric Resistance Training

    Time frame: 12 weeks and 24 weeks

    End of exercise protocol and 12 weeks after completion

Sponsors and collaborators

Lead sponsor

University of New England, Australia

Other

Registry information

Official study title

Cardiovascular Response to Isometric Resistance Training in People With Hypertension for Blood Pressure Management

Important dates

Study start
2016
Primary completion
2016
Study completion
2016
First posted
Jun 1, 2015
Registry last updated
Dec 17, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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