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Active, Not Recruiting

NCT Number: NCT02258035

Isolation of Vitamin D Binding Protein Isoforms From Human Volunteers

The purpose of this study is to isolate genotype-specific DBP/Gc from homozygous human volunteers and use these purified proteins to cross-validate existing or novel assays for this serum protein and to evaluate the binding characteristics of these variants of DBP/Gc for different vitamin D metabolites.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Vitamin D Deficiency Avitaminosis Deficiency Diseases Malnutrition Nutrition Disorders Nutritional and Metabolic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

UZ Leuven

Leuven, 3000, Belgium

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Generally healthy adults (≥ 18 years), non pregnant, with known DBP/Gc genotype

Exclusion criteria

  • Inability to provide written informed consent
  • No children or pregnant women
  • Persons with known abnormal serum proteins

Treatment and study plan

Blood Draw

Other

Sampling of 100-150 ml of blood

Primary outcomes

  1. Vitamin D binding protein binding characteristics (affinity constant)

    Time frame: single blood draw at time of consultation, an expected average 4 years after curative treatment for breast cancer

    In vitro characterization

Secondary outcomes

  1. Correlation coefficient (r) of different DBP assays

    Time frame: single blood draw at time of consultation, an expected average 4 years after curative treatment for breast cancer

    In vitro characterization

Sponsors and collaborators

Lead sponsor

Universitaire Ziekenhuizen KU Leuven

Other

Registry information

Official study title

Isolation of Genotype-specific Isoforms of Human Vitamin D-binding Protein (DBP/Gc)

Important dates

Study start
2014
Primary completion
2016
Study completion
2025
First posted
Oct 7, 2014
Registry last updated
Jul 3, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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