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Completed

NCT Number: NCT00552487

Isolated ACTH Deficiency in Patients With Hashimoto Thyroiditis

The purpose of this study is to determine whether patients with Hashimoto thyroiditis and impaired well-being may have a partial secondary adrenocortical insufficiency.

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Key information

Conditions

Hashimoto Disease ACTH Deficiency, Isolated Adrenal Gland Diseases Adrenal Insufficiency Autoimmune Diseases Endocrine System Diseases Immune System Diseases Thyroid Diseases Thyroiditis Thyroiditis, Autoimmune

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Wuerzburg, Department of Endocrinology

Würzburg, Bavaria, 97080, Germany

About this study

Many patients with Hashimoto thyroiditis who are correctly substituted with thyroid hormones have an impaired well-being. in some people an isolated ACTH deficiency was found.

In this study a 1 µg ACTH test is performed to evaluate the adrenocortical function.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Hashimoto thyroiditis euthyreot thyroid function with levothyroxin therapy written informed consent

Exclusion criteria

  • • hypothyroidism of other origin
  • pregnancy and lactation
  • oral contraception
  • glucocorticoid therapy during the last 2 months
  • History of malignancy or chronic infections (Hepatitis, HIV)

Treatment and study plan

synacthen

Drug

1 µg synacthen in the vein

Other names: ACTH

Primary outcomes

  1. serum cortisol-peak 30 min after ACTH-stimulation

    Time frame: 30 minutes

Secondary outcomes

  1. serum DHEA-peak 30 min. after ACTH-stimulation,DHEA-S, ACTH

    Time frame: 30 minutes

Sponsors and collaborators

Lead sponsor

University of Wuerzburg

Other

Registry information

Important dates

Study start
2005
Study completion
2006
First posted
Nov 2, 2007
Registry last updated
Nov 2, 2007

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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