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Completed

NCT Number: NCT00000254

Isoflurane at Subanesthetic Concentrations - 6

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To test the hypothesis that isoflurane at subanesthetic concentrations does not reduce cold-water immersion pain in healthy volunteers.

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Key information

Conditions

Opioid-related Disorders Chemically-Induced Disorders Mental Disorders Narcotic-Related Disorders Substance-Related Disorders

Age range

21 year–34 year

Sex eligibility

Male

Study type

Interventional

Phase

Phase 2

Primary location

University of Chicago, Anesthesia & Critical Care

Chicago, Illinois, 60637, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Please contact site for information.

Treatment and study plan

40% Nitrous oxide

Drug

Used as pain assay positive control

Sham Comparator

Other

0% isoflurane in oxygen

0.2% isoflurane

Drug

0.4% isoflurane

Drug

0.6% isoflurane

Drug

Primary outcomes

  1. Pain response

    Time frame: Post inhalation

    Effects of inhaled isoflurane on pain from immersion of subject's arm in ice cold water. Nitrous oxide (40%) was used as a positive control to confirm sensitivity of the pain assay.

Sponsors and collaborators

Lead sponsor

University of Chicago

Other

Collaborators

  • National Institute on Drug Abuse (NIDA)

Registry information

Official study title

Isoflurane at Subanesthetic Concentrations

Important dates

Study start
1995
Primary completion
1995
Study completion
1995
First posted
Sep 21, 1999
Registry last updated
May 28, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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