Ischemic Preconditioning and Thiol-disulfide Balance

Various strategies have been proposed to prevent or mitigate the effects of ischemia-reperfusion injury following the use of tourniquets in orthopedic surgery cases. One of them is applying "remote ischemic preconditioning." This randomized controlled trial is planned to evaluate the effectiveness of remote ischemic preconditioning in preventing tourniquet-induced ischemia-reperfusion injury in total knee arthroscopy with dynamic thiol-disulfide homeostasis.

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Key information

Conditions

Tourniquets

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Betul Kozanhan

Konya, 42005, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

ASA I-III patients who will undergo total knee arthroplasty surgery under elective conditions

Exclusion criteria

emergency operation,
Underlying neurological disorder,
Underlying peripheral vascular disease,
other types of concurrent surgery.

Treatment and study plan

Remote Ischemic Preconditioning

Other

Three cycles of 5-min upper limb ischemia and 5-min reperfusion using a blood-pressure cuff inflated to a pressure of systolic blood pressure plus 50 mm Hg.

Other names: RIPC group

sham group

Other

a deflated cuff placed on the upper arm for 30 min

Primary outcomes

thiol/disulfide homeostasis

Time frame: 24th hour after surgery

Thiol/disulphide homeostasis will be determined at preoperatively and just before the tourniquet opened and at the 1st, 6th and 24th hours after the tourniquet is opened.

Sponsors and collaborators

Lead sponsor

Konya Meram State Hospital

Other

Registry information

Official study title

Effect of Ischemic Preconditioning on Dynamic Thiol-disulfide Balance, Randomized Controlled Trial

Important dates

Study start: 2021
Primary completion: 2022
Study completion: 2022
First posted: Oct 18, 2021
Registry last updated: Aug 17, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed