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Completed

NCT Number: NCT01666587

Ischemia Reperfusion: Prostaglandins and Antioxidants

The purposes of this study are two-fold. The first purpose is to determine the effect of taking vitamins on the recovery of an artery (blood vessel) following an induced temporary injury. The second purpose is to determine whether a specific vasodilator is less abundant after the injury and whether this contributes to increased constriction or after the injury. Finally, does vitamin consumption have an effect on the recovery from the injury if one of the substances in the blood that causes vessels to enlarge (dilate) is stopped?

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Key information

Conditions

Ischemic Reperfusion Injury

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Essex

Colchester, Essex, CO4 3SQ, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy males
  • Healthy females

Exclusion criteria

  • Smokers
  • Cardiovascular disease
  • Peripheral vascular disease
  • Neurological deficits
  • Diabetes Type I or II
  • Pregnant women
  • Adverse reactions to Ibuprofen

Treatment and study plan

Antioxidant

Dietary Supplement

Prostaglandin inhibitor (Ibuprophen)

Drug

Other names: ibuprofen

Primary outcomes

  1. Change in flow mediated dilation

    Time frame: Change from baseline at 15 minutes after ischemia-reperfusion injury

    Flow mediated dilation is a measure of vascular function and is measured as the outcome before and after an injury to the inner lining of the artery.

Secondary outcomes

  1. Change in low flow mediated constriction

    Time frame: Change from baseline at 15 minutes after ischemia-reperfusion injury

    low flow mediated constriction is a measure of vascular function and is measured to establish the impact of a vascular injury

Sponsors and collaborators

Lead sponsor

University of Essex

Other

Registry information

Official study title

The Role of Prostaglandin and Anti-oxidant Availability on Recovery From Forearm Ischemia-reperfusion Injury in Humans

Important dates

Study start
2012
Primary completion
2013
Study completion
2013
First posted
Aug 16, 2012
Registry last updated
May 12, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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