Is There an Association Between Quadriceps Strength and Different Markers of Fragility in Patients With Cirrhosis?

Secondary objective: compare the different strength parameters of patients with cirrhosis (strength endurance, rate of strength development) with healthy subjects.

Inclusion criteria

SUBJECT :

• with a diagnosis of liver cirrhosis (regardless of cirrhosis stage and etiology)
• under the care of a physician practising in the University Hospital Estaing in Clermont-Ferrand
• affiliated to the french social security system

Exclusion criteria

SUBJECT:

• with hepatocellular carcinoma
• with HIV infection
• with hepatic encephalopathy grade ≥ 2
• with cognitive dysfunction
• with contraindication for physical activity
• with knee pain/knee disorders
• pregnant or breastfeeding
• under protective supervision (guardianship, curatorship, protection of the court)

Inclusion criteria

for healthy volonteers:

• male subjects aged 52 to 62
• female subjects aged 42 to 60
• BMI between 20 and 30 kg/m2
• no musculoskeletal problems limiting physical activity
• level of physical activity < 3 hours per week
• affiliated to the french social security system

Exclusion criteria

for healthy volonteers:

• medical or surgical history deemed incompatible with the trial by the investigator
• simultaneous participation in a trial involving a drug or medical device, or period of exclusion from such a trial
• participants protected by law (under guardianship, conservatorship, or protection of the court)