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NCT Number: NCT07168551

Is There a Relationship Between Uric Acid Level and Liver Fibrosis in Obese Patients

1. Identifying the association between hyperuricemia and NAFLD can lead to early detection and prevention of liver fibrosis in adult obese patients. 2. Understanding the relationship between hyperuricemia and NAFLD can inform targeted therapy, such as urate-lowering treatment, to potentially slow disease progression.

3 - To examine the relationship between serum uric acid levels and liver fibrosis severity*: Assessing the correlation between serum uric acid levels and the severity of liver fibrosis in adult obese patients with NAFLD.

4- To identify potential mechanisms underlying the association*: Exploring the potential mechanisms by which hyperuricemia may contribute to the development and progression of NAFLD and liver fibrosis in adult obese patients.

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Key information

Conditions

Hyperuricemia Digestive System Diseases Fatty Liver Fibrosis Liver Cirrhosis Liver Diseases Liver Fibrosis NAFLD (Nonalcoholic Fatty Liver Disease) Non-alcoholic Fatty Liver Disease Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

About this study

Hyperuricemia is associated with nonalcoholic fatty liver disease (NAFLD), whereas whether the association differed by hyperuricemia onset age remained unclear. This study sought to investigate the associations of hyperuricemia onset age with the risk of incident NAFLD across adulthood.

Obesity has been demonstrated to show a consistent link with the increased possibility of nonalcoholic fatty liver disease (NAFLD). Since both serum uric acid (SUA) and obesity are essential components of metabolic syndrome (MetS), it is uncertain whether the incidence of NAFLD results from serum uric acid, obesity, or other potential factors based on previous studies.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age: Adults (typically 18-65 years old)

2 - Body Mass Index (BMI): Obese patients with a BMI ≥ 30 kg/m²

3- Hyperuricemia : Elevated serum uric acid levels (typically > 7 mg/dL for men and > 6 mg/dL for women)

Exclusion criteria

  • excessive alcohol consumption ( > 20 gm /day in men and 10 in g /day in women )

2- use of steatogenic within the past 6 months

3- positive test for hepatitis B surface antigen and hepatitis B core antibody

4- Drug induced liver injury and autoimmune hepatitis

5 - cirrhosis and other causes of liver disease

Treatment and study plan

*Lab Methods:* 1- Serum Uric Acid levels 2-Liver Function Tests 3- Lipid Profile . 4- Haemoglobin A1c level . 5- Serum glucose level .

Diagnostic Test

Lab methods

*Imaging Studies:* 1- Ultrasound 2 - FibroScan

Radiation

Imaging

Instruments:* 1- *Automated Analyzers*: Used for blood tests, such as serum uric acid and liver function tests.

Device

Instrument

Primary outcomes

  1. Prevalence of NAFLD

    Time frame: 1 year

    The proportion of adult obese patients with NAFLD in the study population

Secondary outcomes

  1. Serum uric acid level

    Time frame: 1 year

    The serum uric acid level in adult obese patients

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Association of Hyperuricemia and Non Alcoholic Fatty Liver Disease and Liver Fibrosis Risk in Adult Obese Patients

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Sep 11, 2025
Registry last updated
Sep 15, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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